法氏囊作为环境抗原的捕获机制。
The bursa of Fabricius as a trapping mechanism for environmental antigens.
作者信息
Ekino S, Urano T, Fujii H, Kotani M
出版信息
Adv Exp Med Biol. 1985;186:487-93. doi: 10.1007/978-1-4613-2463-8_60.
The bursa of Fabricius was isolated from gut-derived antigens by ligating the bursal duct on the 18th day of incubation. Ligation of the bursal duct (BDL) suppressed the bursal development, spontaneous germinal centre formation in the spleen and the development of serum "natural" agglutinins for bacteria or heteroerythrocytes. Moreover, administration of sterilized cecal contents into the bursal lumen at BDL led to normal level of serum "natural" agglutinins. These findings strongly suggest that the bursa of Fabricius possesses an antigen-dependent process which modulates the development of immune system. Antigen-trapping mechanism of the bursa may supply information about environmental antigens for this process.
在孵化第18天通过结扎法氏囊导管，将法氏囊与源自肠道的抗原隔离开来。法氏囊导管结扎（BDL）抑制了法氏囊的发育、脾脏中生发中心的自发形成以及血清中针对细菌或异种红细胞的“天然”凝集素的发育。此外，在BDL时将无菌盲肠内容物注入法氏囊腔会使血清“天然”凝集素水平恢复正常。这些发现有力地表明，法氏囊具有一个依赖抗原的过程，该过程调节免疫系统的发育。法氏囊的抗原捕获机制可能为这一过程提供有关环境抗原的信息。
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