农药暴露与生活方式与帕金森病运动严重程度之间关联的纵向评估。

Longitudinal assessment of the association between pesticide exposure and lifestyle with Parkinson's disease motor severity.

作者信息

Lüth Theresa, Caliebe Amke, Gabbert Carolin, Sendel Sebastian, Laabs Björn-Hergen, König Inke R, Klein Christine, Trinh Joanne

机构信息

Institute of Neurogenetics, University of Lübeck, Lübeck, Germany.

Institute of Medical Informatics and Statistics, Kiel University and University Hospital Schleswig-Holstein, Kiel, Germany.

出版信息

NPJ Parkinsons Dis. 2025 Jun 12;11(1):164. doi: 10.1038/s41531-025-01010-2.

DOI:10.1038/s41531-025-01010-2

PMID:40506444

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12162858/

Abstract

Longitudinal investigations on the relationship between lifestyle exposures and motor severity are lacking. In this longitudinal study, we included patients with idiopathic Parkinson's disease (iPD) (N = 5139) and LRRK2-related PD (N = 81) from PPMI-Online and Fox Insight. Motor aspects were followed for up to five years. We investigated the association between environmental exposure, lifestyle factors and motor aspect severity over time by applying linear mixed effects models. In LRRK2-PD, black tea consumption was associated with less severe motor aspects (β = -0.51, p = 0.028). In patients with iPD, pesticide exposure was associated with more severe motor aspects over time in PPMI-Online (β = 0.23, p = 3.56 × 10). Lastly, caffeinated soda was associated with more severe motor aspects in patients with iPD from PPMI-Online (β = 0.15, p = 3.84 × 10) and Fox Insight (β = 0.09, p = 0.031). We suggest that pesticide exposure and lifestyle factors may affect motor severity in patients with LRRK2-PD and iPD, demonstrating the impact on patients even after disease onset.

摘要

关于生活方式暴露与运动严重程度之间关系的纵向研究尚属空白。在这项纵向研究中，我们纳入了来自PPMI-Online和Fox Insight的特发性帕金森病（iPD）患者（N = 5139）和与LRRK2相关的帕金森病患者（N = 81）。对运动方面进行了长达五年的跟踪。我们通过应用线性混合效应模型，研究了环境暴露、生活方式因素与运动方面严重程度随时间的关联。在LRRK2-PD中，饮用红茶与运动方面症状较轻相关（β = -0.51，p = 0.028）。在iPD患者中，在PPMI-Online研究中，农药暴露与随时间推移运动方面症状更严重相关（β = 0.23，p = 3.56×10）。最后，在PPMI-Online研究的iPD患者中，含咖啡因汽水与运动方面症状更严重相关（β = 0.15，p = 3.84×10），在Fox Insight研究中也是如此（β = 0.09，p = 0.031）。我们认为，农药暴露和生活方式因素可能会影响LRRK2-PD和iPD患者的运动严重程度，这表明即使在疾病发作后也会对患者产生影响。