Trolese-Mongheal Y, Duchene-Marullaz P, Trolese J F, Leinot M, Lamar J C, Lacroix P
Am J Cardiol. 1985 Oct 1;56(10):677-81. doi: 10.1016/0002-9149(85)91034-3.
Acute myocardial ischemia was produced by ligature of the anterior descending coronary artery on 658 dogs in 3 separate laboratories. Overall, 12% of the dogs died within the first hour (instantaneous death) and 25% within the first 24 hours (sudden death). The sudden death rate was significantly related to the logarithm of the weight of the dogs in the range studied. It varied widely if values from small series, comprising the same number of dogs, were considered. Values became less dispersed as the size of the series increased. In series of 10 dogs, sudden death rates ranged from 0 to 70%, whereas in series of 100 dogs the range was 14 to 36%. Stable values were obtained for 50 to 60 dogs per series. Accordingly, reliable assessment of preventive measures can be made only with experimental series of at least this size.
在3个独立实验室中，通过结扎658只犬的冠状动脉前降支制造急性心肌缺血模型。总体而言，12%的犬在第1小时内死亡（即刻死亡），25%在最初24小时内死亡（猝死）。猝死率与所研究范围内犬体重的对数显著相关。如果考虑包含相同数量犬的小样本系列的值，其变化范围很大。随着样本系列规模的增加，值的离散度变小。在每组10只犬的系列中，猝死率范围为0至70%，而在每组100只犬的系列中，范围为14至36%。每组50至60只犬时可获得稳定值。因此，只有至少这个规模的实验系列才能对预防措施进行可靠评估。
