Scherlag B J, Patterson E, Lazzara R
University of Oklahoma Health Sciences Center, Department of Medicine/Cardiology, Oklahoma City, Oklahoma.
J Electrocardiol. 1990 Jul;23(3):223-30. doi: 10.1016/0022-0736(90)90160-4.
The authors studied the incidence of sudden death by monitoring the ECG after ligation of the left anterior descending coronary artery in 184 dogs. A significant number of sudden deaths (46 dogs) occurred in the cold weather months, November-February (42%), compared to the summer months, July and August (6%). All deaths resulted from ventricular tachyarrhythmias (greater than or equal to 300/min) and occurred between 13 and 22 hours after coronary artery ligation. The survivors (138 dogs) were subjected to electrophysiological study, during which a significantly higher number showed induced sustained monomorphic ventricular tachycardia (VT) (heart rate greater than or equal to 300/min) during the winter months than during the summer months. Heart weight and infarct mass were not significantly different throughout the year. Higher sympathetic tone or catecholamine levels may account for the seasonal variation in sudden death during evolving myocardial infarction.
作者通过监测184只犬左前降支冠状动脉结扎后的心电图来研究猝死发生率。与夏季的7月和8月（6%）相比，在寒冷的11月至2月期间发生了大量猝死（46只犬，42%）。所有死亡均由室性快速性心律失常（心率大于或等于300次/分钟）导致，且发生在冠状动脉结扎后13至22小时之间。对存活的138只犬进行了电生理研究，在此期间，冬季出现诱发性持续性单形性室性心动过速（VT，心率大于或等于300次/分钟）的犬数量显著多于夏季。全年心脏重量和梗死灶质量无显著差异。较高的交感神经张力或儿茶酚胺水平可能是心肌梗死进展过程中猝死季节性变化的原因。
