Ferrari Sara, Galla Rebecca, Mulè Simone, Molinari Claudio, Uberti Francesca
Laboratory of Physiology, Department for Sustainable Development and Ecological Transition, 13100 Vercelli, Italy.
Noivita Srls, Spin Off University of Piemonte Orientale, Strada Privata Curti 7, 28100 Novara, Italy.
Nutrients. 2025 May 26;17(11):1807. doi: 10.3390/nu17111807.
: Venous hypertension is the primary cause of the disorder known as chronic venous insufficiency (CVI), which affects the lower extremities' venous system. Because of its biological proper ties, which include anti-inflammatory, antioxidant, and vascular tone enhancement, medicinal herbs and natural substances are highly recommended for treating CVI. Therefore, this study examined the advantages of a novel combination composed of hypersmin, pumpkin seed and amaranthus extracts (named MIX) in modulating different parameters involved with CVI. : The capacity of these natural compounds to pass across the intestinal barrier and reach the bloodstream was examined using a 3D intestinal barrier model that mimics oral ingestion. The biological effects of the MIX were then compared to those of a commercial product using an in vitro CVI model. : The findings demonstrate that the new MIX significantly reduced inflammation while increasing nitric oxide production. The MIX was more successful than the commercial product in reducing apoptosis while restoring vasal tone and extracellular matrix activity. : This work has therefore demonstrated the positive benefits of extracts from amaranthus, pumpkin seed and hypersmin in the context of CVI, raising the prospect of creating a unique combination for patients with CVI.
静脉高压是被称为慢性静脉功能不全（CVI）的病症的主要原因，该病症会影响下肢静脉系统。由于药草和天然物质具有抗炎、抗氧化和增强血管张力等生物学特性，因此强烈推荐使用它们来治疗CVI。因此，本研究考察了由金丝桃素、南瓜籽和苋菜提取物组成的新型组合（命名为MIX）在调节与CVI相关的不同参数方面的优势。使用模拟口服摄入的3D肠道屏障模型研究了这些天然化合物穿过肠道屏障并进入血液的能力。然后使用体外CVI模型将MIX的生物学效应与一种商业产品的生物学效应进行比较。研究结果表明，新的MIX显著减轻了炎症，同时增加了一氧化氮的产生。在恢复血管张力和细胞外基质活性的同时，MIX在减少细胞凋亡方面比商业产品更成功。因此，这项研究证明了苋菜、南瓜籽和金丝桃素提取物在CVI方面的积极益处，为为CVI患者创造独特组合带来了前景。
