Luo Jiaohua, Wang Jia, Qiu Zhiqun, Zeng Hui, Tan Yao, Huang Yujing, Shu Weiqun
Department of Environmental Hygiene, College of Preventive Medicine, Army Medical University, Chongqing 400038, China.
Department of Medical English, College of Basic Medicine, Army Medical University, Chongqing 400038, China.
Nutrients. 2025 May 30;17(11):1875. doi: 10.3390/nu17111875.
: Drinking natural bicarbonate water (NBW) has been associated with decreased bone resorption, improved lipid profile, and reduced cardiovascular risk. However, the specific molecular mechanisms underlying these effects remain unclear. : Twenty 10-month-old female Sprague Dawley rats were randomly allocated to two experimental groups; one received purified water (PW) and the other was administered NBW over a three-month intervention period. The liver's metabolic properties were analyzed using a comprehensive quantitative targeted metabolomics technique. : Sixty-nine differential metabolites (67 upregulated and 2 downregulated) were detected in the NBW group compared to the PW group. These metabolites included 34 amino acids, 11 carbohydrates, 7 fatty acids, 7 short-chain fatty acids (SCFAs), and 10 other biomolecules. Furthermore, 10 metabolic pathways exhibited significant alterations: aminoacyl-tRNA biosynthesis; alanine-aspartate-glutamate metabolism; nitrogen-butanoate metabolism; histidine-phenylalanine metabolism; arginine-proline metabolism; glycine-serine-threonine metabolism; valine-leucine-isoleucine biosynthesis; and phenylalanine-tyrosine-tryptophan biosynthesis. The NBW group demonstrated a statistical tendency toward lower urinary calcium/creatinine ratio compared to the PW group. : These findings suggest that the consumption of NBW may induce positive nitrogen balance, enhance the level of certain polyunsaturated fatty acids and SCFAs, and improve calcium balance. Such metabolic alterations could potentially explain the beneficial effects of NBW.
饮用天然碳酸氢盐水（NBW）与骨吸收减少、血脂改善以及心血管风险降低有关。然而，这些作用背后的具体分子机制仍不清楚。
将20只10个月大的雌性Sprague Dawley大鼠随机分为两个实验组；一组饮用纯净水（PW），另一组在为期三个月的干预期内给予NBW。使用全面的定量靶向代谢组学技术分析肝脏的代谢特性。
与PW组相比，NBW组检测到69种差异代谢物（67种上调和2种下调）。这些代谢物包括34种氨基酸、11种碳水化合物、7种脂肪酸、7种短链脂肪酸（SCFA）和10种其他生物分子。此外，10条代谢途径表现出显著改变：氨酰-tRNA生物合成；丙氨酸-天冬氨酸-谷氨酸代谢；氮-丁酸代谢；组氨酸-苯丙氨酸代谢；精氨酸-脯氨酸代谢；甘氨酸-丝氨酸-苏氨酸代谢；缬氨酸-亮氨酸-异亮氨酸生物合成；以及苯丙氨酸-酪氨酸-色氨酸生物合成。与PW组相比，NBW组的尿钙/肌酐比值有统计学上的降低趋势。
这些发现表明，饮用NBW可能诱导正氮平衡，提高某些多不饱和脂肪酸和SCFA的水平，并改善钙平衡。这种代谢改变可能解释了NBW的有益作用。
