Skonieczna Karolina, Wiciun Olimpia, Pinkowska Katarzyna, Dominiak Tomasz, Grzelakowska Klaudyna, Kasprzak Michał, Szymański Paweł, Kubica Jacek, Niezgoda Piotr
Student Research Club of Cardiology, L. Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, 85-027 Bydgoszcz, Poland.
Department of Cardiology and Internal Medicine, L. Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, 85-094 Bydgoszcz, Poland.
J Clin Med. 2025 May 23;14(11):3672. doi: 10.3390/jcm14113672.
The SARS-CoV-2 virus, identified in December 2019, led to a global pandemic resulting in over 6 million deaths. While most COVID-19 cases present mild symptoms, severe complications can develop in immunocompromised patients, including impacts on the heart. This study aimed to compare angiographic findings and hospitalization outcomes in acute coronary syndrome (ACS) patients with and without COVID-19. This retrospective study analyzed 174 ACS patients (105 men, 69 women) hospitalized in the Department of Cardiology and Internal Medicine of the Nicolaus Copernicus University in Bydgoszcz and Regional Hospital in Grudziądz (2019-2021). Forty-eight of them had COVID-19. The analyzed parameters included, inter alia, the coronary artery disease severity, the presence of thrombosis, survival rates, risk factors, and prior endovascular procedures. COVID-19 patients with ACS showed a higher rate of thrombus in non-culprit vessels (6.25% vs. 0.0%, = 0.0293), and overall survival was significantly lower (68.75% vs. 93.65%, < 0.0001), while prior PCI rates were higher in non-COVID patients (34.13% vs. 6.25%, = 0.0002). Procedure times were shorter for non-COVID patients, reducing catheterization lab exposure. Other procedural factors showed no significant differences. This study highlights significant differences in coronary angiography and hospitalization outcomes between ACS patients with and without COVID-19. The extended stay of COVID-19 patients in the catheterization lab poses an increased risk to medical staff, and the presence of thrombi underscores the need for effective antithrombotic strategies. The significant association of COVID-19 with hypercoagulability and its role in precipitating acute coronary syndromes necessitates the development of specific clinical guidelines to manage these patients effectively.
2019年12月发现的严重急性呼吸综合征冠状病毒2（SARS-CoV-2）引发了一场全球大流行，导致超过600万人死亡。虽然大多数新冠肺炎病例症状较轻，但免疫功能低下的患者可能会出现严重并发症，包括对心脏的影响。本研究旨在比较合并和未合并新冠肺炎的急性冠状动脉综合征（ACS）患者的血管造影结果和住院结局。这项回顾性研究分析了在比得哥什的哥白尼大学心脏病学和内科以及格鲁琼兹地区医院住院的174例ACS患者（105名男性，69名女性）（2019年至2021年）。其中48例患有新冠肺炎。分析的参数尤其包括冠状动脉疾病严重程度、血栓形成情况、生存率、危险因素和既往血管内介入治疗情况。合并新冠肺炎的ACS患者非罪犯血管血栓形成率较高（6.25%对0.0%，P = 0.0293），总体生存率显著较低（68.75%对93.65%，P < 0.0001），而非新冠肺炎患者既往PCI率较高（34.13%对6.25%，P = 0.0002）。非新冠肺炎患者的手术时间较短，减少了导管室暴露时间。其他手术因素无显著差异。本研究强调了合并和未合并新冠肺炎的ACS患者在冠状动脉造影和住院结局方面的显著差异。新冠肺炎患者在导管室停留时间延长给医务人员带来了更高风险，并突出了血栓形成表明需要有效的抗栓策略。新冠肺炎与高凝状态的显著关联及其在引发急性冠状动脉综合征中的作用，使得有必要制定特定的临床指南以有效管理这些患者。
