Poydock M E, Harguindey S, Hart T, Takita H, Kelly D
Am J Clin Oncol. 1985 Jun;8(3):266-9. doi: 10.1097/00000421-198506000-00013.
The present study was designed to test the effect of a combination of dehydroascorbic acid (DHA) and hydroxycobalamin (vitamin B12) on the survival of mice bearing L1210 leukemia. Results showed a significant increase in survival of treated mice compared with controls (p less than or equal to 0.0001) (Student's t-test). This positive effect was significantly lost when DHA was substituted by ascorbic acid (AA) in the same experimental conditions. In vitro findings also revealed that the DHA-B12 combination specifically inhibited mitoses of L1210 cells while non-neoplastic L929 cells were not affected.
本研究旨在测试脱氢抗坏血酸（DHA）和羟钴胺素（维生素B12）联合使用对患有L1210白血病小鼠存活率的影响。结果显示，与对照组相比，经治疗的小鼠存活率显著提高（p≤0.0001）（学生t检验）。在相同实验条件下，当DHA被抗坏血酸（AA）替代时，这种积极效果显著丧失。体外研究结果还显示，DHA-B12组合可特异性抑制L1210细胞的有丝分裂，而非肿瘤性L929细胞则不受影响。
