Poydock M E
Cancer Research Institute, Mercyhurst College, Erie, PA 16546.
Am J Clin Nutr. 1991 Dec;54(6 Suppl):1261S-1265S. doi: 10.1093/ajcn/54.6.1261s.
A combination of dehydroascorbic acid and hydroxycobalamin (vitamin B-12) inhibited mitoses of tumors in mice. The present study was performed to test the effect of these vitamins on the survival of mice bearing carcinomas and leukemias. In each assay 40 mice received 0.1 mL ip tumor cells (x10(5)). After 24 h, 20 mice were injected with 0.2 mL (0.4 g/kg body wt) of the vitamins daily for 10 d. All controls died by day 19, but greater than 50% of the treated mice were alive after 60 d. In vitro findings revealed inhibition of mitoses in L1210 leukemia cells, but not in normal L929 cells. In recent research with cobalt-ascorbate plus vitamin C, we demonstrated that when B-12 is combined with vitamin C, the cobalt nucleus of B-12 attaches to a carbon on vitamin C, forming cobalt ascorbate. Tests proved that cobalt ascorbate plus vitamin C also inhibited tumor cells.
脱氢抗坏血酸与羟钴胺素（维生素B - 12）的组合可抑制小鼠肿瘤的有丝分裂。本研究旨在测试这些维生素对患有癌症和白血病小鼠存活率的影响。在每次试验中，40只小鼠经腹腔注射0.1 mL肿瘤细胞（10⁵个）。24小时后，20只小鼠每天注射0.2 mL（0.4 g/kg体重）的维生素，持续10天。所有对照组小鼠在第19天死亡，但超过50%的经治疗小鼠在60天后仍存活。体外研究结果显示，L1210白血病细胞的有丝分裂受到抑制，但正常L929细胞未受影响。在最近关于抗坏血酸钴加维生素C的研究中，我们证明当B - 12与维生素C结合时，B - 12的钴核会附着在维生素C的一个碳原子上，形成抗坏血酸钴。测试证明，抗坏血酸钴加维生素C也能抑制肿瘤细胞。
