Rueda José Antonio Blanco, López-Valverde Antonio, Marquez-Vera Antonio, Ferreira Natàlia Dos Reis, Macedo de Sousa Bruno, López-Valverde Nansi
Department of Surgery, University of Salamanca, 37008 Salamanca, Spain.
Biomedical Research Institute of Salamanca (IBSAL), 37007 Salamanca, Spain.
J Clin Med. 2025 May 28;14(11):3778. doi: 10.3390/jcm14113778.
: Temporomandibular disorders are a heterogeneous group of degenerative musculoskeletal conditions that present a series of symptoms such as pain, dysfunction of the masticatory muscles and/or temporomandibular joints, structural abnormalities, and limitation or alteration of mandibular movements. The objective of this study was to evaluate the efficacy of photobiomodulation therapy with low-power laser in patients refractory to treatment with botulinum toxin type A. : A multicenter prospective experimental pilot study was proposed, in which 10 patients between 33 and 68 (50 ± 11.2) years old participated, assigned to a laser group (940 nm diode laser) who had previously been treated with a minimum of three doses of botulinum toxin type A without obtaining positive results. The patients underwent four photobiomodulation sessions over 4 weeks (registered at ClinicalTrials NCT06915064). Painful symptoms were evaluated using a visual analog scale at different locations, the pressure pain threshold using algometry, and the maximum vertical mandibular movement determined using digital calipers. The results were recorded four weeks after the end of treatment. Adverse effects were also evaluated. : Pain in the masticatory muscles was reduced in 70% of patients with statistically significant values ( = 0.002); a total of 60% of patients showed a considerable reduction in joint noise with outstanding statistical significance ( = 0.015). The majority of participants reported a reduction in the intensity of headaches after treatment. However, it only produced a slight improvement in maximum mouth opening and lateral excursions. Algometric values in the masticatory muscles showed improvement only in the left-sided irradiated muscles. : Photobiomodulation therapy is a non-invasive treatment option for temporomandibular disorders that generates positive effects in cases refractory to treatment with botulinum toxin type A.
颞下颌关节紊乱病是一组异质性的退行性肌肉骨骼疾病，表现为一系列症状，如疼痛、咀嚼肌和/或颞下颌关节功能障碍、结构异常以及下颌运动受限或改变。本研究的目的是评估低功率激光光生物调节疗法对A型肉毒毒素治疗无效患者的疗效。：本研究提出了一项多中心前瞻性实验性试点研究，10名年龄在33至68岁（50±11.2岁）之间的患者参与其中，被分配到激光组（940nm二极管激光），这些患者此前至少接受过三剂A型肉毒毒素治疗但未取得阳性结果。患者在4周内接受了4次光生物调节治疗（在ClinicalTrials NCT06915064注册）。使用视觉模拟量表在不同部位评估疼痛症状，使用压力痛觉计评估压力痛阈值，使用数字卡尺确定下颌最大垂直运动。在治疗结束四周后记录结果。还评估了不良反应。：70%的患者咀嚼肌疼痛减轻，具有统计学显著意义（P = 0.002）；共有60%的患者关节弹响明显减轻，具有显著统计学意义（P = 0.015）。大多数参与者报告治疗后头痛强度降低。然而，它仅使最大开口度和侧向运动略有改善。咀嚼肌的压力痛觉计值仅在左侧照射的肌肉中显示出改善。：光生物调节疗法是颞下颌关节紊乱病的一种非侵入性治疗选择，对A型肉毒毒素治疗无效的病例有积极效果。
