Blanco-Rueda José A, López-Valverde Antonio, Márquez-Vera Antonio, Méndez-Sánchez Roberto, López-García Eva, López-Valverde Nansi
Instituto de Investigación Biomédica de Salamanca (IBSAL), University Hospital, 37007 Salamanca, Spain.
Instituto de Investigación Biomédica de Salamanca (IBSAL), Department of Surgery, University of Salamanca, 37007 Salamanca, Spain.
Life (Basel). 2023 Jan 28;13(2):345. doi: 10.3390/life13020345.
Temporomandibular disorders are a common pathology affecting up to 70% of the population, with a maximum incidence in young patients. We used a sample of twenty patients recruited in the Maxillofacial Surgery Service of the University Hospital of Salamanca (Spain), who met the inclusion criteria, with unilateral painful symptomatology of more than three months' duration. All patients were randomly treated by intramuscular and intra-articular injections of botulinum toxin (100 U) in eight predetermined points. Pain symptomatology was assessed by the visual analog scale (VAS) at the different locations, together with joint symptomatology, at baseline and six weeks after treatment. Adverse effects were also evaluated. In 85% of the patients, pain upon oral opening improved and 90% showed improvement in pain upon mastication. A total of 75% of the patients reported improvement in joint clicking/noise. Headaches improved or disappeared in 70% of the patients treated. Despite the limitations of the study and the preliminary results, intramuscular and intra-articular infiltrations with botulinum toxin were effective in the treatment of symptoms associated with temporomandibular disorders (TMDs), with minimal adverse effects.
颞下颌关节紊乱病是一种常见的病理状况，影响着高达70%的人群，在年轻患者中发病率最高。我们选取了西班牙萨拉曼卡大学医院颌面外科招募的20名符合纳入标准的患者作为样本，这些患者均有持续超过三个月的单侧疼痛症状。所有患者均在八个预定部位接受了肌肉内和关节内注射肉毒杆菌毒素（100单位）的随机治疗。在基线期和治疗后六周，通过视觉模拟量表（VAS）评估不同部位的疼痛症状以及关节症状。同时也对不良反应进行了评估。85%的患者张口时疼痛得到改善，90%的患者咀嚼时疼痛有所改善。共有75%的患者报告关节弹响/杂音有所改善。70%接受治疗的患者头痛症状得到改善或消失。尽管该研究存在局限性且结果初步，但肌肉内和关节内注射肉毒杆菌毒素对治疗与颞下颌关节紊乱病（TMDs）相关的症状有效，且不良反应最小。
