Muntean Maximilian, Ilies Radu Alexandru, Pop Ioan Constantin, Urian Laura, Vlad Ioan Catalin, Achimas-Cadariu Patriciu
Department of Plastic Surgery, "Prof. Dr. I. Chiricuță" Institute of Oncology, 400015 Cluj-Napoca, Romania.
Department of Plastic and Reconstructive Surgery, "Iuliu Hațieganu" University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania.
J Clin Med. 2025 Jun 1;14(11):3902. doi: 10.3390/jcm14113902.
: One of the most controversial issues in contemporary plastic surgery is the potential association between textured breast implants and breast implant-associated anaplastic large cell lymphoma (BIA-ALCL). Despite growing concern, the safety profile of various breast implant types regarding BIA-ALCL remains unclear. The primary aim of this review was to critically evaluate recent evidence to determine if certain implant textures pose a higher risk of BIA-ALCL. : A literature search was performed using the PubMed database for articles published between 2020 and 2024. The keyword "BIA-ALCL" guided the search. Inclusion criteria were articles written in English, freely accessible in full-text, and specifically addressing implant types and the epidemiology of BIA-ALCL. Single case reports, case series, and animal studies were excluded. From an initial pool of 153 articles, 17 publications, comprising original research, surveys, reports from surgical societies, and reviews, met the inclusion criteria and were analyzed. : Thirteen of the seventeen analyzed studies supported a potential association between textured breast implants and an increased risk of developing BIA-ALCL. However, four studies reported insufficient evidence or inconclusive data regarding this association, highlighting a significant gap in the current understanding of the disease. : Most of the analyzed studies indicate textured breast implants as potential risk factors for developing BIA-ALCL. Nevertheless, the rarity of cases and limited available data necessitate additional robust research to confirm these findings conclusively. Further investigations will be essential to establish comprehensive clinical guidelines and enhance patient safety in breast implant procedures.
当代整形手术中最具争议的问题之一是有纹理的乳房植入物与乳房植入物相关间变性大细胞淋巴瘤(BIA-ALCL)之间的潜在关联。尽管人们越来越关注,但各种类型的乳房植入物在BIA-ALCL方面的安全性仍然不明确。本综述的主要目的是批判性地评估近期证据,以确定某些植入物纹理是否会带来更高的BIA-ALCL风险。
使用PubMed数据库对2020年至2024年发表的文章进行文献检索。关键词“BIA-ALCL”指导检索。纳入标准为用英文撰写、可免费获取全文且专门涉及植入物类型和BIA-ALCL流行病学的文章。排除单病例报告、病例系列和动物研究。在最初的153篇文章中,有17篇出版物,包括原创研究、调查、外科协会报告和综述,符合纳入标准并进行了分析。
在17项分析研究中,有13项支持有纹理的乳房植入物与发生BIA-ALCL风险增加之间存在潜在关联。然而,有4项研究报告称关于这种关联的证据不足或数据不确定,凸显了目前对该疾病理解上的重大差距。
大多数分析研究表明有纹理的乳房植入物是发生BIA-ALCL的潜在风险因素。然而,病例罕见且可用数据有限,需要进行更多有力研究来最终证实这些发现。进一步的调查对于制定全面的临床指南和提高乳房植入手术中的患者安全性至关重要。