Giuliani Eugenia, Donà Maria Gabriella, Zaccarelli Mauro, Stingone Christof, Gianserra Laura, Capodieci Stella, Cafaro Valentina, Fulgenzio Chiara, Latini Alessandra, Giuliani Massimo
STI/HIV Unit, San Gallicano Dermatological Institute IRCCS, 00144 Rome, Italy.
Scientific Direction, San Gallicano Dermatological Institute IRCCS, 00144 Rome, Italy.
J Clin Med. 2025 Jun 4;14(11):3962. doi: 10.3390/jcm14113962.
: Anogenital warts (AGWs) represent the most common clinical manifestation of human papillomavirus (HPV) infection. The analysis of AGW time trends helps to investigate possible changes over time and monitor the impact of HPV vaccines on HPV-associated morbidity. : AGWs diagnosed from 1991 to 2022 at a centre belonging to the Italian STI Surveillance Network were analysed in terms of their numbers and the socio-behavioural characteristics of the patients and then compared over the course of three decades. The time trends, overall and by transmission category, were investigated by joinpoint analysis. : In total, 9781 AGWs were diagnosed [61.9% in men who have sex with women (MSW)]. Individuals aged 25-34 years (36.9%), those with one recent partner (52.0%), and those with no previous STIs (87.8%) accounted for the majority of diagnoses. The HIV prevalence among individuals tested for HIV was 136/3098 (4.4%, 95% CI: 3.7-5.2). AGW diagnoses showed a mild decrease from 1991 to 2004, followed by a significant increase up to 2013 (the highest peak over the entire study period) and a significant decline thereafter, until the most recent years. During 2011-2022, diagnoses in women who have sex with men (WSM) decreased for those aged up to 24 years-the age class that could potentially have included women vaccinated against HPV. : AGWs have declined in recent years. The decrease in the proportion of diagnoses in young WSM may reflect the female immunisation campaign in Italy. Nonetheless, there is still a need to promote vaccine uptake to reduce the AGW burden.
肛门生殖器疣（AGW）是人类乳头瘤病毒（HPV）感染最常见的临床表现。对AGW时间趋势的分析有助于调查随时间可能发生的变化，并监测HPV疫苗对HPV相关发病率的影响。对1991年至2022年期间在意大利性传播感染监测网络所属中心诊断出的AGW，从其数量以及患者的社会行为特征方面进行分析，然后在三十年的时间里进行比较。通过连接点分析研究总体及按传播类别划分的时间趋势。总共诊断出9781例AGW[与女性发生性行为的男性（MSW）中占61.9%]。25至34岁的个体（36.9%）、近期有一个性伴侣的个体（52.0%）以及既往无其他性传播感染的个体（87.8%）占诊断病例的大多数。接受HIV检测的个体中HIV流行率为136/3098（4.4%，95%CI：3.7 - 5.2）。AGW诊断病例数从1991年至2004年呈轻度下降，随后至2013年显著增加（整个研究期间的最高峰），此后显著下降，直至最近几年。在2011 - 2022年期间，与男性发生性行为的女性（WSM）中，24岁及以下年龄组（该年龄组可能包括接种了HPV疫苗的女性）的诊断病例数有所下降。近年来AGW有所减少。年轻WSM诊断比例的下降可能反映了意大利的女性免疫接种活动。尽管如此，仍有必要促进疫苗接种以减轻AGW负担。
