Kuldyushev Nikita A, Simonenko Sergey Y, Goreninskii Semen I, Pallaeva Tatiana N, Zamyatnin Andrey A, Parodi Alessandro
Research Center for Translational Medicine, Sirius University of Science and Technology, 354340 Sochi, Russia.
Additive Technologies Center, Tomsk Polytechnic University, Lenina av., 30, 634050 Tomsk, Russia.
Int J Mol Sci. 2025 May 26;26(11):5119. doi: 10.3390/ijms26115119.
Vitamin B12 (B12), a crucial water-soluble vitamin, plays an essential role in various cellular functions, including DNA synthesis and cellular metabolism. This review explores recent advancements in B12 delivery systems and their potential applications in drug delivery. The unique absorption pathways of B12, which involve specific binding proteins and receptors, are highlighted, emphasizing the vitamin's protective mechanisms that enhance its bioavailability. The review discusses the intricate multi-protein network involved in B12 metabolism and the implications of B12 deficiency, which can lead to significant health issues, including neurological and hematological disorders. Additionally, the potential of B12 as a drug carrier to improve the pharmacokinetic properties of poorly bioavailable medications is examined. The findings suggest that optimizing B12 delivery could enhance therapeutic outcomes in nanomedicine and other clinical applications.
维生素B12（B12）是一种至关重要的水溶性维生素，在包括DNA合成和细胞代谢在内的各种细胞功能中发挥着重要作用。本综述探讨了B12递送系统的最新进展及其在药物递送中的潜在应用。强调了B12独特的吸收途径，其中涉及特定的结合蛋白和受体，突出了该维生素增强其生物利用度的保护机制。该综述讨论了参与B12代谢的复杂多蛋白网络以及B12缺乏的影响，B12缺乏会导致严重的健康问题，包括神经和血液系统疾病。此外，还研究了B12作为药物载体改善生物利用度差的药物的药代动力学特性的潜力。研究结果表明，优化B12递送可以提高纳米医学和其他临床应用的治疗效果。
