Baușic Alexandra Irma Gabriela, Scurtu Francesca, Manu Andrei, Matasariu Daniela Roxana, Brătilă Elvira
Department of Obstetrics and Gynecology, "Carol Davila" University of Medicine and Pharmacy, 020021 Bucharest, Romania.
Department of Obstetrics and Gynecology, "Prof. Dr. Panait Sîrbu" Obstetrics and Gynecology Hospital, 060251 Bucharest, Romania.
Int J Mol Sci. 2025 May 27;26(11):5144. doi: 10.3390/ijms26115144.
Endometriosis is a complex gynaecological disorder characterised by the presence of endometrial-like tissue outside the uterus, leading to chronic inflammation, pain, and infertility. Recent research suggests that gut microbiota may play a crucial role in the pathogenesis and progression of endometriosis by modulating immune responses and oestrogen metabolism. This study investigates the intestinal microbiota composition in women with endometriosis and its potential as a disease diagnosis and severity biomarker. Stool samples from nine patients diagnosed with endometriosis were analysed using the GI Effects Comprehensive Stool Profile test. The tests revealed significant dysbiosis, particularly an altered Firmicutes/Bacteroidetes ratio and increased levels of Bacteroidetes. Inflammatory markers, including β-glucuronidase and secretory IgA, were also elevated, suggesting a potential link between gut microbiota and systemic inflammation in endometriosis. While our findings align with previous studies, further research with larger cohorts is necessary to validate these observations. Understanding the role of the microbiome in endometriosis could open new avenues for noninvasive diagnostic tools in endometriosis and microbiota-targeted therapies.
子宫内膜异位症是一种复杂的妇科疾病，其特征是子宫外存在类似子宫内膜的组织，导致慢性炎症、疼痛和不孕。最近的研究表明，肠道微生物群可能通过调节免疫反应和雌激素代谢，在子宫内膜异位症的发病机制和进展中发挥关键作用。本研究调查了子宫内膜异位症患者的肠道微生物群组成及其作为疾病诊断和严重程度生物标志物的潜力。使用GI Effects综合粪便分析测试对9名被诊断为子宫内膜异位症的患者的粪便样本进行了分析。测试显示存在明显的菌群失调，特别是厚壁菌门/拟杆菌门的比例改变以及拟杆菌门水平升高。包括β-葡萄糖醛酸酶和分泌型免疫球蛋白A在内的炎症标志物也升高，这表明肠道微生物群与子宫内膜异位症中的全身炎症之间可能存在联系。虽然我们的研究结果与之前的研究一致，但需要对更大的队列进行进一步研究以验证这些观察结果。了解微生物群在子宫内膜异位症中的作用可能为子宫内膜异位症的非侵入性诊断工具和以微生物群为靶点的治疗开辟新途径。
