Khatir Zenaba, Leitão Alexandra
Environmental Science Center, Qatar University, Doha 2713, Qatar.
LEMAR, University of Brest/CNRS/Ifremer/IRD, F-29280 Plouzané, France.
Int J Mol Sci. 2025 Jun 4;26(11):5389. doi: 10.3390/ijms26115389.
Over the past four decades, bivalves have become sentinel organisms in genotoxicity research due to their ecological relevance and sensitivity to environmental contaminants. This integrative review critically examines the evolution of genotoxicity in bivalves, from early cytogenetic assays to advanced transcriptomic approaches. It highlights key methodological developments, geographical research trends, and the recent integration of multi-endpoint analyses for a more robust, consistent environmental risk assessment. By synthesizing data from four decades of research, we provide a comprehensive overview of current knowledge while also critically identifying persistent challenges and suggesting directions for future research to allow better evaluation and mitigation of the genetic impacts of marine pollution.
在过去的四十年里，双壳贝类因其与生态的相关性以及对环境污染物的敏感性，已成为遗传毒性研究中的指示生物。本综合综述批判性地审视了双壳贝类遗传毒性研究的发展历程，从早期的细胞遗传学检测到先进的转录组学方法。它突出了关键的方法学进展、地理研究趋势，以及近期多终点分析的整合，以实现更稳健、一致的环境风险评估。通过综合四十年来的研究数据，我们提供了当前知识的全面概述，同时批判性地识别出持续存在的挑战，并为未来研究提出方向，以便更好地评估和减轻海洋污染的遗传影响。
