Huh Jungmoo
Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea.
Plants (Basel). 2025 May 25;14(11):1608. doi: 10.3390/plants14111608.
The Onocleaceae family, a small group within the Pteridophytes, comprises four genera, but has been phytochemically studied mainly for , , and . To date, a total of 91 compounds have been isolated from these three species, including 15 flavonoids, 48 flavonoid glycosides, 6 stilbenes, 4 isocoumarins, 2 phthalides, 3 chromones, 2 lignan glycosides, 8 isoprenoid derivatives, and 3 phenolic compounds. Notably, most flavonoids and flavonoid glycosides possess -methyl groups at the C-6 and/or C-8 positions, with several conjugated to ()-3-hydroxy-3-methylglutaryl (HMG) moieties. Although not all isolates have been evaluated for their pharmacological activities, several compounds have demonstrated bioactivities such as antiviral, anti-inflammatory, α-glucosidase inhibitory, aldose reductase inhibitory, and antioxidant effects.
球子蕨科是蕨类植物中的一个小类群，包含四个属，但主要针对[具体植物名称1]、[具体植物名称2]和[具体植物名称3]进行了植物化学研究。迄今为止，已从这三个物种中分离出总共91种化合物，包括15种黄酮类化合物、48种黄酮苷、6种芪类化合物、4种异香豆素、2种苯酞类化合物、3种色酮类化合物、2种木脂素苷、8种类异戊二烯衍生物和3种酚类化合物。值得注意的是，大多数黄酮类化合物和黄酮苷在C-6和/或C-8位具有甲基，其中几种与（）-3-羟基-3-甲基戊二酰（HMG）部分共轭。尽管并非所有分离物都已评估其药理活性，但几种化合物已显示出抗病毒、抗炎、α-葡萄糖苷酶抑制、醛糖还原酶抑制和抗氧化等生物活性。
