水蕨中的类黄酮及其抗流感病毒（H1N1）活性。
Flavonoids from Matteuccia struthiopteris and Their Anti-influenza Virus (H1N1) Activity.
机构信息
†College of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China.
§Department of Natural Products Chemistry, College of Pharmacy, China Medical University, Shenyang 110001, People's Republic of China.
出版信息
J Nat Prod. 2015 May 22;78(5):987-95. doi: 10.1021/np500879t. Epub 2015 Apr 30.
Seven new flavonoid glycosides (1-7), matteflavosides A-G, together with 12 known flavonoids (8-19) were isolated from the rhizomes of Matteuccia struthiopteris (L.) Todar. Their structures were established via the analyses of extensive spectroscopic data. All compounds were evaluated for their anti-influenza virus (H1N1) activity using the neuraminidase inhibition assay. The results showed that compound 7 exhibited significant inhibitory activity against the H1N1 influenza virus neuraminidase with an EC50 value of 6.8 ± 1.1 μM and an SI value of 34.4, and compounds 8 and 17 showed moderate inhibitory activity.
从总状毛茛中分离得到了 7 个新的黄酮苷类化合物（1-7），即马提苷 A-G，以及 12 个已知的黄酮类化合物（8-19）。通过对大量光谱数据的分析，确定了它们的结构。所有化合物均通过神经氨酸酶抑制试验评估了其抗流感病毒（H1N1）活性。结果表明，化合物 7 对 H1N1 流感病毒神经氨酸酶具有显著的抑制活性，EC50 值为 6.8±1.1μM，SI 值为 34.4，化合物 8 和 17 具有中等抑制活性。
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