Zăvoi Andreea-Alina, Dreancă Alexandra, Magyari Klara, Baia Lucian, Ober Ciprian, Oana Liviu
Faculty of Veterinary Medicine, University of Agricultural Science and Veterinary Medicine, 400372 Cluj-Napoca, Romania.
Nanostructured Materials and Bio-Nano-Interfaces Center, Interdisciplinary Research Institute on Bio-Nano-Sciences, Babes-Bolyai University, 400084 Cluj-Napoca, Romania.
Materials (Basel). 2025 May 27;18(11):2529. doi: 10.3390/ma18112529.
Injuries characterized by significant loss of skeletal muscle tissue volume, known as volumetric muscle loss (VML), lead to substantial impairment in functional capabilities. Natural repair processes and existing medical interventions fall short of fully restoring function post-VML. Despite progress in the VML field, there is an unsatisfactory success rate, donor site morbidity, and inefficient reconstruction of lost muscle tissue. This leads to persistent strength and functional deficits, impacting the quality of life for VML patients. In recent years, studies have explored the potential of bioactive glasses (BGs) as crucial materials in regenerating tissues beyond the skeletal system. BG, used mainly in bone engineering, can aid muscle repair by releasing ions like calcium and phosphate to stimulate cellular response. However, current BG composites struggle to match the mechanical properties of soft tissues, limiting seamless healing. This review summarizes recent advances in various BG structures studied for skeletal muscle tissue regeneration.
以骨骼肌组织体积显著丧失为特征的损伤，即容积性肌肉损失（VML），会导致功能能力严重受损。自然修复过程和现有的医学干预措施都无法在VML后完全恢复功能。尽管在VML领域取得了进展，但成功率仍不尽人意，供体部位存在并发症，且丢失肌肉组织的重建效率低下。这导致持续的力量和功能缺陷，影响VML患者的生活质量。近年来，研究探索了生物活性玻璃（BGs）作为骨骼系统以外组织再生关键材料的潜力。BG主要用于骨工程，可通过释放钙和磷酸盐等离子来刺激细胞反应，从而辅助肌肉修复。然而，目前的BG复合材料难以匹配软组织的力学性能，限制了无缝愈合。本综述总结了为骨骼肌组织再生而研究的各种BG结构的最新进展。
