Prompinichpong Kreevith, Suwanna Nirut, Hunprasit Vachira, Thongbai Amonrat, Theerapan Wutthiwong, Thengchaisri Naris, Sattasathuchana Panpicha
Kasetsart University Veterinary Teaching Hospital, Bangkhen Campus, Faculty of Veterinary Medicine, Kasetsart University, Bangkok 10900, Thailand.
Department of Companion Animal Clinical Sciences, Faculty of Veterinary Medicine, Kasetsart University, Bangkok 10900, Thailand.
Animals (Basel). 2025 May 22;15(11):1504. doi: 10.3390/ani15111504.
Epilepsy is the most common neurological disorder in cats. However, information on the long-term outcomes and predictive survival factors based on neurological and clinicopathological findings is limited. We aimed to evaluate the clinical manifestations, survival rates, and hazard factors influencing survival in cats with epilepsy by analyzing the medical records of 90 cats diagnosed via brain magnetic resonance imaging (MRI). The cats were divided into the survival and non-survival groups. Univariate and multivariable logistic regression analyses were conducted to identify the significant survival factors. The mortality rates at one and two years were 33.2% and 37.8%, respectively. The median age of cats in the non-survival and survival group were 3 and 1 years, respectively. Age over 7 years ( = 0.002), paresis ( = 0.001), structural brain lesions ( = 0.015), leukocytosis ( = 0.001), neutrophilia ( = 0.001), hyperproteinemia ( = 0.037), hypoalbuminemia ( = 0.001), hyperglobulinemia ( = 0.003), and an elevated neutrophil-to-lymphocyte ratio ( = 0.041), were associated with an increased mortality rate. A multivariable analysis identified several predictors of early mortality in cats with epilepsy, including age over 7 years ( = 0.045), presence with paresis ( = 0.012), structural brain lesions ( = 0.042), leukocytosis ( = 0.005), and hypoalbuminemia ( = 0.030). Older age and structural brain lesions were shown to be key predictors of mortality and were important for prognosis prediction and management.
癫痫是猫最常见的神经系统疾病。然而，基于神经学和临床病理检查结果的长期预后及生存预测因素的信息有限。我们旨在通过分析90只经脑磁共振成像（MRI）诊断为癫痫的猫的病历，评估癫痫猫的临床表现、生存率及影响生存的危险因素。将这些猫分为存活组和非存活组。进行单因素和多因素逻辑回归分析以确定显著的生存因素。1年和2年的死亡率分别为33.2%和37.8%。非存活组和存活组猫的中位年龄分别为3岁和1岁。7岁以上（P = 0.002）、轻瘫（P = 0.001）、脑结构病变（P = 0.015）、白细胞增多（P = 0.001）、中性粒细胞增多（P = 0.001）、高蛋白血症（P = 0.037）、低白蛋白血症（P = 0.001）、高球蛋白血症（P = 0.003）以及中性粒细胞与淋巴细胞比值升高（P = 0.041）与死亡率增加相关。多因素分析确定了癫痫猫早期死亡的几个预测因素，包括7岁以上（P = 0.045）、存在轻瘫（P = 0.012）、脑结构病变（P = 0.042）、白细胞增多（P = 0.005）和低白蛋白血症（P = 0.030）。年龄较大和脑结构病变被证明是死亡的关键预测因素，对预后预测和管理很重要。
