Despa Andreea, Musteata Mihai, Solcan Gheorghe
Neurology Service, Faculty of Veterinary Medicine, Ion Ionescu de la Brad Iași University of Life Sciences (IULS), 700489 Iași, Romania.
Internal Medicine Clinic, Faculty of Veterinary Medicine, Ion Ionescu de la Brad Iași University of Life Sciences (IULS), 700489 Iași, Romania.
Vet Sci. 2024 Sep 4;11(9):408. doi: 10.3390/vetsci11090408.
The role of neuroinflammation in epileptogenesis has been previously explored, and several biomarkers have been identified as being relevant in assessing the intensity of the inflammatory process. In human medicine, an increased C reactive protein (CRP) blood concentration and/or neutrophil-to-lymphocyte ratio (NLR) is considered a constant finding of epileptic activity. In veterinary medicine, only a few studies have been published regarding both of these topics.
HYPOTHESIS/OBJECTIVES: Our aim was to assess the C reactive protein blood concentration and the neutrophil-to-lymphocyte ratio in epileptic dogs, regardless of etiology.
This retrospective study was based on changes in routine blood parameters in 59 dogs with epileptic activity.
An increased C reactive protein concentration was observed mostly in the dogs affected by structural epilepsy, and all epileptic dogs displayed abnormal neutrophil-to-lymphocyte values.
Based on the authors' knowledge, this is the first report regarding the NLR in epileptic dogs. Both the CRP concentration and the NLR might be considered feasible non-specific markers of the neuroinflamation involved in epileptogenesis and might be used in the diagnosis of and therapeutic approach to cluster seizures in dogs with idiopathic epilepsy and in patients with structural epilepsy. Dogs diagnosed with IEis and high CRP concentrations and NLRs may be subject to non-documented cluster seizures. Both CRP and the NLR have limited diagnostic value in dogs with reactive seizures.
神经炎症在癫痫发生中的作用此前已被探讨，并且已确定几种生物标志物与评估炎症过程的强度相关。在人类医学中，血液中C反应蛋白（CRP）浓度升高和/或中性粒细胞与淋巴细胞比值（NLR）被认为是癫痫活动的一个持续表现。在兽医学中，关于这两个主题的研究仅有少数发表。
假设/目的：我们的目的是评估癫痫犬的血液C反应蛋白浓度和中性粒细胞与淋巴细胞比值，而不考虑病因。
这项回顾性研究基于59只患有癫痫活动的犬的常规血液参数变化。
C反应蛋白浓度升高主要在受结构性癫痫影响的犬中观察到，并且所有癫痫犬的中性粒细胞与淋巴细胞值均异常。
据作者所知，这是关于癫痫犬NLR的首份报告。CRP浓度和NLR都可被视为癫痫发生中涉及的神经炎症的可行非特异性标志物，并且可用于特发性癫痫犬和结构性癫痫患者群集性发作的诊断和治疗方法中。被诊断为特发性癫痫且CRP浓度和NLR较高的犬可能会出现未记录的群集性发作。CRP和NLR在反应性癫痫犬中的诊断价值有限。
