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社会经济地位、抗抑郁药物的使用以及因常见精神障碍致残后重返工作岗位的情况。

Socioeconomic status, antidepressant use, and return to work after disability due to common mental disorders.

作者信息

Leppänen Helena, Kampman Olli, Autio Reija, Tanskanen Antti, Taipale Heidi, Karolaakso Tino, Rissanen Päivi, Näppilä Turkka, Pirkola Sami

机构信息

Faculty of Medicine and Health Technology, https://ror.org/033003e23Tampere University, Tampere, Finland.

Department of Psychiatry, The Wellbeing Services County of Pirkanmaa, Finland.

出版信息

Eur Psychiatry. 2025 Jun 13;68(1):e79. doi: 10.1192/j.eurpsy.2025.10046.

Abstract

BACKGROUND

Common mental disorders (CMDs) are significant causes of work disability. Low socioeconomic status (SES) is a known risk factor for CMDs and work disability, one possible reason being poorer treatment adherence. We aimed to study the realization of pharmacological treatment and antidepressant adherence in patients with CMDs 3 years before and 3 years after being granted a disability pension (DP) and the role of SES in this. We also studied whether antidepressant adherence is associated with return to work (RTW) after a temporary DP.

METHODS

Information on all persons granted a DP due to CMD between 2010 and 2012 in Finland ( = 12,388) was retrieved from national registers, which included medical, socioeconomic, and sociodemographic information of the subjects. We used the PRE2DUP method to estimate drug use periods and regression analyses to study associations between SES, taking medications, and RTW.

RESULTS

Prevalence of taking antidepressants increased towards the DP grant and decreased thereafter, but 14.6% of subjects did not take antidepressants or antipsychotics at all during the study period. Of SES factors, only income was positively associated with antidepressant adherence, lasting over a year. Antidepressant adherence was not associated with RTW.

CONCLUSIONS

An alarming result was the absence of recommended medication in fewer than every seventh patient estimated to be disabled due to pharmacologically treatable psychiatric disorders. Contrary to expectations, SES had only a minor predictive role in antidepressant adherence in this patient group. Contrary to taking antidepressants, rehabilitation was associated with RTW. The results adduced the importance of CMD treatment optimization regardless of SES.

摘要

背景

常见精神障碍(CMD)是工作残疾的重要原因。社会经济地位低下(SES)是CMD和工作残疾的已知风险因素,一个可能的原因是治疗依从性较差。我们旨在研究获得残疾抚恤金(DP)前3年和后3年患有CMD的患者药物治疗的实施情况和抗抑郁药依从性,以及SES在此过程中的作用。我们还研究了临时DP后抗抑郁药依从性是否与重返工作岗位(RTW)相关。

方法

从国家登记处获取2010年至2012年期间在芬兰因CMD获得DP的所有人员(n = 12388)的信息,其中包括受试者的医疗、社会经济和社会人口统计学信息。我们使用PRE2DUP方法估计药物使用期,并通过回归分析研究SES、服药与RTW之间的关联。

结果

服用抗抑郁药的患病率在DP发放前上升,之后下降,但14.6%的受试者在研究期间根本未服用抗抑郁药或抗精神病药。在SES因素中,只有收入与持续一年以上的抗抑郁药依从性呈正相关。抗抑郁药依从性与RTW无关。

结论

一个令人担忧的结果是,估计因可药物治疗的精神障碍而残疾的患者中,每七名患者中就有不到一名患者未接受推荐药物治疗。与预期相反,SES在该患者群体的抗抑郁药依从性方面仅起次要预测作用。与服用抗抑郁药相反,康复与RTW相关。结果表明,无论SES如何,优化CMD治疗都很重要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2997/12188336/9467659a745e/S0924933825100461_fig1.jpg

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