Maslan M J, Graham M D, Flood L M
Am J Otol. 1985 Sep;6(5):435-7.
A patient presented with a bilateral profound hearing loss of sudden onset following a two-month neurologic illness. Microscopy and culture of cerebrospinal fluid revealed Cryptococcus neoformans. Treatment with amphotericin B and 5-fluorocytosine failed to restore hearing. Auditory brain stem response and electrical promontory stimulation suggest a profound deafness with poor neuronal survival. This is consistent with previous temporal bone histopathology reports in individuals dying of cryptococcal meningitis, suggesting a retrocochlear lesion. It is important to exclude this occult pathologic factor in a patient with the sudden onset of sensorineural deafness prior to embarking upon a course of steroid therapy.
一名患者在患神经系统疾病两个月后突然出现双侧严重听力丧失。脑脊液显微镜检查和培养发现新型隐球菌。两性霉素B和5-氟胞嘧啶治疗未能恢复听力。听性脑干反应和电刺激岬提示严重耳聋且神经元存活不良。这与先前死于隐球菌性脑膜炎患者的颞骨组织病理学报告一致，提示为蜗后病变。在开始类固醇治疗疗程之前，对突发感音神经性耳聋的患者排除这种隐匿性病理因素很重要。
