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颈动脉血运重建对认知功能的影响:一项关于有症状和无症状病例的研究。

Impact of carotid artery revascularization on cognitive function: a study of symptomatic and asymptomatic cases.

作者信息

Wu Sensen, Ning Yachan, Wang Hui, Pan Dikang, Guo Julong, Wang Cong, Wang Chunmei, Gu Yongquan, Guo Lianrui

机构信息

Department of Vascular Surgery, Xuanwu Hospital, Capital Medical University, Beijing, China.

Department of Intensive Care Medicine, Xuanwu Hospital, Capital Medical University, Beijing, China.

出版信息

Front Neurol. 2025 May 29;16:1452495. doi: 10.3389/fneur.2025.1452495. eCollection 2025.

Abstract

OBJECTIVE

To investigate and compare changes in cognitive function following revascularization between patients with symptomatic and asymptomatic carotid stenosis.

METHODS

From April 2019 to April 2022, patients carotid artery stenosis who were treated with carotid endarterectomy (CEA) or carotid artery stenting (CAS) were recruited for this study. The Montreal Cognitive Assessment (MoCA) instrument was used to evaluate cognitive function preoperatively and at 3, 6, and 12 months postoperatively. Patients were divided into two groups based on the neurological symptoms, repeated measures ANOVA was used for comparisons.

RESULTS

A total of 89 patients who met the criteria were enrolled and completed 1-year follow-up, divided into symptomatic group (32 patients) and asymptomatic group (57 patients). Baseline data showed no significant differences in clinical characteristics between the two groups. At 3, 6, and 12 months after carotid revascularization, the total MoCA and delayed recall scores for both groups showed significant increases compared to baseline levels. In patients with asymptomatic, attention also showed improvement at 3, 6 months compared to baseline ( < 0.05).

CONCLUSION

Carotid revascularization has a positive impact on cognitive function improvement, particularly in delayed recall and attention.

摘要

目的

研究并比较有症状和无症状颈动脉狭窄患者血管重建术后认知功能的变化。

方法

2019年4月至2022年4月,招募接受颈动脉内膜切除术(CEA)或颈动脉支架置入术(CAS)治疗的颈动脉狭窄患者进行本研究。使用蒙特利尔认知评估(MoCA)工具在术前以及术后3、6和12个月评估认知功能。根据神经症状将患者分为两组,采用重复测量方差分析进行比较。

结果

共纳入89例符合标准的患者并完成1年随访,分为有症状组(32例)和无症状组(57例)。基线数据显示两组临床特征无显著差异。颈动脉血管重建术后3、6和12个月,两组的MoCA总分和延迟回忆得分与基线水平相比均显著提高。在无症状患者中,与基线相比,注意力在3、6个月时也有所改善(P<0.05)。

结论

颈动脉血管重建对认知功能改善有积极影响,尤其是在延迟回忆和注意力方面。

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