Gong Yu, Zhang Xudong, Hao Xiaomin, Liu Jipeng, Yue Bingnan, Liu Chuan, Xia Tianqi, Yang Yi, Tu Longteng, Qiu WeiJie, Liu Yu, Liu Qingguo
School of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese Medicine, Beijing, China.
Department of Chinese Medicine, Beijing Jishuitan Hospital, Beijing, China.
Front Endocrinol (Lausanne). 2025 May 29;16:1543991. doi: 10.3389/fendo.2025.1543991. eCollection 2025.
Satoyoshi syndrome (also known as Komuragaeri disease ) is a rare disorder of unknown etiology, with progressive muscle spasms, whole-body hair loss, and diarrhea as its main symptoms, particularly progressive skeletal muscle spasms and pain. Because of the lack of a clear etiology and pathogenesis of Satoyoshi syndrome, Western medicine lacks established effective therapies, and the long-term prognosis of the treatment of this disease is poor, unable to improve multiple symptoms simultaneously and prevent the recurrence of the disease. In recent years, acupuncture has been increasingly explored as a complementary treatment for autoimmune diseases. It is believed to exert its effects by modulating the neuroendocrine-immune network, enhancing immune cell function, and restoring homeostatic pathways. These mechanisms enable acupuncture to provide immune modulation, ultimately achieving a holistic and bidirectional regulatory effect.
We report the case of a 54-year-old male police officer who had Satoyoshi syndrome for more than five years. After six months of acupuncture treatment, the patient's chronic diarrhea completely disappeared, and the occasional painful muscle cramps and insomnia significantly improved. After six months of follow-up, the patient's condition was stable.
In this study, we believe that acupuncture therapy is of great significance for the improvement of diarrhea, immediate and long-term analgesia, and stabilization of the Satoyoshi syndrome.
痛性痉挛综合征（也称为小森蛙怪病）是一种病因不明的罕见疾病，主要症状为进行性肌肉痉挛、全身脱发和腹泻，尤其是进行性骨骼肌痉挛和疼痛。由于痛性痉挛综合征缺乏明确的病因和发病机制，西医缺乏既定的有效治疗方法，该疾病治疗的长期预后较差，无法同时改善多种症状并预防疾病复发。近年来，针灸作为自身免疫性疾病的辅助治疗方法越来越受到探索。据信它通过调节神经内分泌-免疫网络、增强免疫细胞功能和恢复稳态途径来发挥作用。这些机制使针灸能够提供免疫调节，最终实现整体双向调节作用。
我们报告了一名54岁男性警官的病例，他患有痛性痉挛综合征超过五年。经过六个月的针灸治疗，患者的慢性腹泻完全消失，偶尔出现的肌肉疼痛性痉挛和失眠也有明显改善。经过六个月的随访，患者病情稳定。
在本研究中，我们认为针灸疗法对改善痛性痉挛综合征的腹泻、即时和长期镇痛以及病情稳定具有重要意义。
