Okamoto Hiroki, Li Shuo, Nakamura Yuumi
Department of Dermatology, The University of Osaka Graduate School of Medicine, Osaka, Japan.
Cutaneous Allergy and Host Defense, Immunology Frontier Research Center, The University of Osaka, Osaka, Japan.
JID Innov. 2025 May 4;5(4):100377. doi: 10.1016/j.xjidi.2025.100377. eCollection 2025 Jul.
The skin microbiome plays a crucial role in the pathogenesis of atopic dermatitis (AD), a chronic inflammatory skin disorder strongly associated with microbial dysbiosis, particularly colonization. However, the mechanisms linking to AD remain insufficiently understood. This review explores the impact of the quorum-sensing (QS) system, particularly the accessory gene regulator Agr, in AD development and progression. By examining key microbial-host interactions, we provide insights into how QS influences skin inflammation and dysbiosis. Furthermore, we discuss the potential of microbiome-targeted therapeutic strategies to mitigate or prevent AD, highlighting their implications for future research and clinical applications.
皮肤微生物群落在特应性皮炎（AD）的发病机制中起着关键作用，AD是一种与微生物群落失调，尤其是与定殖密切相关的慢性炎症性皮肤病。然而，与AD相关的机制仍未得到充分了解。本综述探讨了群体感应（QS）系统，特别是辅助基因调节因子Agr，在AD发生和发展中的影响。通过研究关键的微生物-宿主相互作用，我们深入了解了QS如何影响皮肤炎症和群落失调。此外，我们讨论了以微生物群为靶点的治疗策略减轻或预防AD的潜力，强调了它们对未来研究和临床应用的意义。
