氧化应激标志物F2-异前列腺素和早老素-1在临床诊断的阿尔茨海默病中的作用
Role of Oxidative Stress Markers F2-Isoprostanes and Presenilin-1 in Clinical Diagnosed Alzheimer's Diseases.
作者信息
Timalsina Dilip Raj, Abichandani Leela, Ambad Ranjit
机构信息
Department of Biochemistry, Datta Meghe Medical College, Nagpur, Datta Meghe Institute of Higher Education and Research (DU) Sawangi Wardha, Maharashtra, India.
Department of Biochemistry, Jawaharlal Nehru Medical College, Wardha, Datta Meghe Institute of Higher Education and Research (DU) Sawangi Wardha, Maharashtra, India.
出版信息
J Pharm Bioallied Sci. 2025 May;17(Suppl 1):S905-S908. doi: 10.4103/jpbs.jpbs_1789_24. Epub 2025 Apr 25.
INTRODUCTION
Alzheimer's disease (AD), a neurodegenerative disorder closely associated with aging, is characterized by progressive cognitive decline and is a leading cause of dementia worldwide. Oxidative stress plays a pivotal role in AD's pathophysiology, contributing to amyloid-beta accumulation, neurofibrillary tangles, and neuronal damage.
AIM
This study investigates the potential of F2-isoprostanes and Presenilin-1 (PSEN1) as biomarkers for oxidative stress and their association with clinically diagnosed Alzheimer's disease.
MATERIALS AND METHODS
A comparative cross-sectional study will be conducted, enrolling 50 AD patients and 50 age-matched healthy controls from the Vidarbha region. Serum levels of F2-isoprostanes and PSEN1 will be measured using advanced analytical techniques, and their correlation with AD progression will be analyzed statistically.
RESULTS AND CONCLUSION
The findings are expected to provide insights into the diagnostic and prognostic value of these markers, offering potential avenues for early detection and therapeutic intervention in Alzheimer's disease.
引言
阿尔茨海默病（AD）是一种与衰老密切相关的神经退行性疾病，其特征为进行性认知衰退，是全球痴呆症的主要病因。氧化应激在AD的病理生理学中起关键作用，导致β淀粉样蛋白积累、神经原纤维缠结和神经元损伤。
目的
本研究调查F2-异前列腺素和早老素-1（PSEN1）作为氧化应激生物标志物的潜力及其与临床诊断的阿尔茨海默病的关联。
材料与方法
将进行一项比较横断面研究，从维达巴地区招募50名AD患者和50名年龄匹配的健康对照。使用先进分析技术测量血清中F2-异前列腺素和PSEN1的水平，并对它们与AD进展的相关性进行统计学分析。
结果与结论
预期研究结果将为这些标志物的诊断和预后价值提供见解，为阿尔茨海默病的早期检测和治疗干预提供潜在途径。
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