Role of Oxidative Stress Markers F2-Isoprostanes and Presenilin-1 in Clinical Diagnosed Alzheimer's Diseases.

INTRODUCTION

Oxidative stress is an important component in the pathogenesis of Alzheimer's disease (AD).

MATERILS AND METHODS

A comparative cross-sectional study was conducted on 140 participants who made up 70 subjects diagnosed with AD and 70 controls. Serum levels of F2-isoprostanes and Presenilin 1 were estimated using ELISA. These markers were significantly elevated in the serum of AD patients, suggesting them to be potential biomarkers for early diagnosis and disease progression.

AIM AND OBJECTIVE

In this study, the level of F2-isoprostanes and Presenilin 1 was determined in patients clinically diagnosed with AD, thus establishing a possible relationship between heightened markers for oxidative stress and progression of AD.

RESULTS

The results showed significantly elevated levels of F2-isoprostanes (179.38 ± 3.01 pg/mL vs 85.89 ± 0.97 pg/mL, < 0.0001) and Presenilin 1 (93.26 ± 2.39 ng/mL vs 49.46 ± 0.78 ng/mL, < 0.0001) in AD patients compared to controls. Additionally, markers of lipid peroxidation, such as malondialdehyde (MDA), were elevated in AD patients, while antioxidant defense mechanisms, including glutathione (GSH) and superoxide dismutase (SOD), were significantly impaired ( < 0.0001).

CONCLUSION

This study provides compelling evidence that oxidative stress, as shown by elevated levels of F2-isoprostanes and Presenilin 1, plays a crucial role in the onset of AD.