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与正常新生儿相比，宫内生长受限胎儿的孤立性单脐动脉及脐血管的组织形态计量学变化

Isolated Single Umbilical Artery and Histomorphometric Changes of Umbilical Blood Vessels in Intrauterine Growth Retarded Foetus in Comparison to Normal Neonates.

作者信息

Kumar Dinesh, Soni Jagdish S

机构信息

PhD Scholar, Department of Anatomy, Parul Institute of Medical Sciences & Research, Faculty of Medicine, Parul University, Waghodia, Vadodara, Gujarat, India.

Professor and Head, Department of Anatomy, Parul Institute of Medical Sciences & Research, Faculty of Medicine, Parul University, Waghodia, Vadodara, Gujarat, India.

出版信息

J Pharm Bioallied Sci. 2025 May;17(Suppl 1):S770-S773. doi: 10.4103/jpbs.jpbs_543_25. Epub 2025 Apr 25.

DOI:10.4103/jpbs.jpbs_543_25
PMID:40510974
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12156640/
Abstract

BACKGROUND

Three vessels-one vein and two arteries-allow the fetus and placenta to exchange waste, oxygen, and nutrients in the umbilical cord. Single umbilical artery (SUA), a congenital abnormality with one umbilical artery, can occur in some pregnancies.

MATERIALS AND METHODS

The current observational study was conducted at the Parul Institute of Medical Sciences and Research, Waghodia, Vadodara, Gujarat. Ten percent formalin was used to preserve 5 cm segment of the placental cord after delivery. Paraffin-embedded slices were produced, and H and E staining was performed on a 3 μm segment.

RESULTS

This study compared 125 normal and 125 intrauterine growth restriction (IUGR) infant umbilical cords. IUGR neonates had significantly thinner umbilical vessel walls than normal newborns, although their cross-sectional area was similar between sexes.

CONCLUSION

The thickness of umbilical cord blood arteries affects IUGR, according to this study. These large vessel wall thickness changes may indicate IUGR or associated disorders.

摘要

背景

三条血管——一条静脉和两条动脉——使胎儿和胎盘能够在脐带中交换废物、氧气和营养物质。单脐动脉（SUA）是一种先天性异常，即脐带中只有一条脐动脉，在某些妊娠中可能会出现。

材料与方法

本观察性研究在古吉拉特邦瓦多达拉市瓦戈迪亚的帕鲁医学科学与研究学院进行。分娩后，用10%的福尔马林保存5厘米长的胎盘脐带段。制作石蜡包埋切片，并对3微米厚的切片进行苏木精-伊红染色。

结果

本研究比较了125条正常婴儿脐带和125条宫内生长受限（IUGR）婴儿脐带。IUGR新生儿的脐血管壁明显比正常新生儿薄，尽管其横截面积在性别之间相似。

结论

根据本研究，脐动脉的厚度会影响IUGR。这些大血管壁厚度的变化可能表明IUGR或相关疾病。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3b6/12156640/4b98f0a352e6/JPBS-17-770-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3b6/12156640/0f73b8ca4733/JPBS-17-770-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3b6/12156640/9f05047511f5/JPBS-17-770-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3b6/12156640/ce8e1fecbeb4/JPBS-17-770-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3b6/12156640/a286cb1bbbf0/JPBS-17-770-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3b6/12156640/4b98f0a352e6/JPBS-17-770-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3b6/12156640/0f73b8ca4733/JPBS-17-770-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3b6/12156640/9f05047511f5/JPBS-17-770-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3b6/12156640/ce8e1fecbeb4/JPBS-17-770-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3b6/12156640/a286cb1bbbf0/JPBS-17-770-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3b6/12156640/4b98f0a352e6/JPBS-17-770-g005.jpg

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本文引用的文献

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Human umbilical cord and its vessels: a histomorphometric study in difference severity of hypertensive disorders of pregnancy.人脐带及其血管：妊娠高血压疾病不同严重程度的组织形态计量学研究
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Pregnancy prognosis associated with an isolated single umbilical artery in twin pregnancy.
双胎妊娠中孤立性单脐动脉的妊娠预后
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Computerized microscope morphometry of umbilical vessels from pregnancies with intrauterine growth retardation and abnormal umbilical artery Doppler.对伴有宫内生长受限及脐动脉多普勒异常的妊娠中脐血管进行计算机显微镜形态测定。
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