不同镇静方案用于管理成年患者牙科焦虑症的安全性和有效性：一项随机对照试验
Safety and Efficacy of Different Sedation Protocols in Managing Dental Anxiety in Adult Patients: A Randomized Controlled Trial.
作者信息
Georgeno G L, Shinde Madhuri, Datla Praveen Kumar Varma, Malleedi Shanthi, Jahagirdar Abhishek, Nagella Sai Prannoy, Maria Rahul, Singh Shanaya
机构信息
Department of OMFS, Rajas Dental College and Hospital, Kaavalkinaru, Tirunelveli, Tamil Nadu, India.
Almas Hospital, Kottakkal, Malappuram, Kerala, India.
出版信息
J Pharm Bioallied Sci. 2025 May;17(Suppl 1):S442-S444. doi: 10.4103/jpbs.jpbs_1450_24. Epub 2025 Feb 25.
INTRODUCTION
Dental anxiety is a significant barrier to effective dental treatment, often resulting in delayed care. Various sedation protocols are utilized to manage this anxiety, but comparative data on their safety and efficacy are limited.
METHODS
This randomized controlled trial compared the safety and efficacy of oral midazolam, nitrous oxide, and intravenous (IV) sedation in managing dental anxiety in adult patients. Key parameters included anxiety reduction using the Visual Analog Scale (VAS), time to onset of sedation, patient satisfaction, and adverse effects.
RESULTS
Patients receiving IV sedation showed the fastest onset and highest anxiety reduction, but oral midazolam exhibited fewer side effects. Patient satisfaction was highest with IV sedation.
CONCLUSION
IV sedation was found to be the most effective in reducing anxiety, while oral midazolam offered better safety. Future studies should further explore patient-specific protocols.
引言
牙科焦虑是有效牙科治疗的重大障碍，常常导致治疗延迟。人们采用各种镇静方案来应对这种焦虑，但关于其安全性和有效性的比较数据有限。
方法
这项随机对照试验比较了口服咪达唑仑、笑气和静脉镇静在管理成年患者牙科焦虑方面的安全性和有效性。关键参数包括使用视觉模拟量表（VAS）降低焦虑程度、镇静起效时间、患者满意度和不良反应。
结果
接受静脉镇静的患者起效最快，焦虑减轻程度最高，但口服咪达唑仑的副作用较少。静脉镇静的患者满意度最高。
结论
发现静脉镇静在减轻焦虑方面最有效，而口服咪达唑仑安全性更佳。未来研究应进一步探索针对患者的方案。
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