Guo Shuang, Hu Yingqing, Ling Li, Yang Zhuangzhuang, Wan Luxuan, Yang Xiaosong, Lei Min, Guo Xiying, Ren Zhanhong
Hubei Key Laboratory of Diabetes and Angiopathy, Xianning Medical College, Hubei University of Science and Technology, Xianning, Hubei 437100, P.R. China.
School of Basic Medical Sciences, Xianning Medical College, Hubei University of Science and Technology, Xianning, Hubei 437100, P.R. China.
Int J Mol Med. 2025 Aug;56(2). doi: 10.3892/ijmm.2025.5566. Epub 2025 Jun 13.
Heart failure is a major health issue that threatens life and health. Previous studies have shown that heart failure is the terminal stage of arrhythmia, dilated cardiomyopathy, hypertension, hypertrophic cardiomyopathy and myocardial infarction. The pathological mechanisms through which cardiovascular diseases result in heart failure include myocardial fibrosis and hypertrophy, myocardial cell death, mitochondrial dysfunction, vascular remodeling and calcium dysregulation. However, the detailed molecular mechanisms of heart failure remain elusive because of its complexity, hindering the development of intervention approaches for heart failure. The present study reviewed recent research progress on heart failure and provided references and strategies for the prevention and treatment of heart failure.
心力衰竭是一个威胁生命健康的重大健康问题。先前的研究表明，心力衰竭是心律失常、扩张型心肌病、高血压、肥厚型心肌病和心肌梗死的终末期阶段。心血管疾病导致心力衰竭的病理机制包括心肌纤维化和肥厚、心肌细胞死亡、线粒体功能障碍、血管重塑和钙调节异常。然而，由于心力衰竭的复杂性，其详细的分子机制仍不清楚，这阻碍了心力衰竭干预方法的发展。本研究综述了心力衰竭的最新研究进展，并为心力衰竭的预防和治疗提供了参考和策略。
