Kaya Duru, Savitskaya Ulliana, Bloom Nicole
Division of Psychology and Language Sciences, Faculty of Brain Sciences.
Division of Medicine, Faculty of Medical Sciences, University College London.
Psychiatr Genet. 2025 Aug 1;35(4):87-95. doi: 10.1097/YPG.0000000000000396. Epub 2025 Apr 23.
Predictive genetic testing for major depressive disorder (MDD) has become a widespread technological advancement to aid the process of early diagnosis and treatment selection. Despite these tests' growing accessibility to the public, scant attention has been given to the behavioural changes that test-takers experience in response to undergoing the procedure and learning about their predisposition to MDD. The current paper aimed to be the first literature review to compile and evaluate the existing evidence demonstrating both the desirable and potentially harmful psychological responses following these tests. Studies portray a complicated picture, including desirable changes in the domains of felt stigma, lifestyle habits, and beliefs in treatment efficacy; as well as noteworthy deteriorations in perceived agency, fatalistic thoughts, and negativity bias in retrospective memory. In light of these findings, our review concludes that clear psychoeducation before testing is crucial to ensure that behavioural changes are predominantly beneficial for test-takers.
针对重度抑郁症（MDD）的预测性基因检测已成为一项广泛应用的技术进步，有助于早期诊断和治疗选择过程。尽管这些检测对公众来说越来越容易获得，但对于受测者在接受检测并了解自己患MDD的易感性后所经历的行为变化，却很少有人关注。本文旨在成为第一篇文献综述，汇编和评估现有证据，以证明这些检测后出现的既有益又可能有害的心理反应。研究呈现出一幅复杂的图景，包括在感知耻辱感、生活方式习惯和对治疗效果的信念等方面出现的有益变化；以及在感知能动性、宿命论思想和回顾性记忆中的消极偏差方面出现的显著恶化。鉴于这些发现，我们的综述得出结论，检测前进行清晰的心理教育对于确保行为变化对受测者主要有益至关重要。
