Weinstein A G
Ann Allergy. 1985 Oct;55(4):563-7.
Several theophylline pharmacologic strategies were tested for the forgetful medication-dependent asthmatic who frequently initiates treatment from below the therapeutic range of 10 to 20 micrograms/mL. Theodur was found to give comparable if not higher levels (two, eight, and 24 hours) starting from 0 microgram/mL than Slophyllin Gyrocap during a multiple dose 28-hour study. In a single dose 12-hour study, Theodur 100-mg tablets gave higher levels during the first nine hours than Theodur 200-mg tablets. Theodur 100-mg tablets may be preferred for the forgetful asthmatic who can sustain pulmonary function despite greater fluctuation with theophylline levels.
对于那些经常在低于10至20微克/毫升治疗范围开始治疗的健忘且依赖药物治疗的哮喘患者，测试了几种茶碱药理学策略。在一项为期28小时的多剂量研究中，发现从0微克/毫升开始，Theodur在2小时、8小时和24小时时的血药浓度即便不比Slophyllin Gyrocap高，也与之相当。在一项为期12小时的单剂量研究中，Theodur 100毫克片剂在前9小时的血药浓度高于Theodur 200毫克片剂。对于那些尽管茶碱水平波动较大但仍能维持肺功能的健忘哮喘患者，Theodur 100毫克片剂可能是更优选择。
