EZH2突变增加了淋巴瘤中染色质状态的异质性。
EZH2 mutations increase the heterogeneity of chromatin states in lymphoma.
作者信息
Holoch Daniel, Margueron Raphaël
机构信息
Institut Curie, INSERM U934/CNRS UMR 3215, Paris Sciences et Lettres Research University, Sorbonne University, Paris, France.
出版信息
PLoS Biol. 2025 Jun 13;23(6):e3003211. doi: 10.1371/journal.pbio.3003211. eCollection 2025 Jun.
Abstract
A recent study in PLoS Biology used simultaneous measurements of histone modifications in single cells to reveal that EZH2 gain-of-function mutations profoundly reprogram chromatin states in B-cell lymphoma, while also increasing their cell-cell heterogeneity.
摘要
《公共科学图书馆·生物学》最近的一项研究通过对单细胞中的组蛋白修饰进行同步测量，揭示了EZH2功能获得性突变在深刻重塑B细胞淋巴瘤中的染色质状态的同时，还增加了其细胞间的异质性。
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