Mandelbaum J, Plachot M
C R Acad Hebd Seances Acad Sci D. 1977 Mar 14;284(11):953-5.
The comparative study of fertilization, with the same sperm sample, of in vitro matured oocytes and freshly ovulated ones, shows a new aspect of mammalian oocyte maturation. While 80% of freshly ovulated oocytes are fertilized, in vitro matured eggs are not fertilizable. They present the ability to be penetrated by spermatozoa 4 to 6 hrs. only after HCG injection. This is therefore not on tubal influence but depends on an oocyte specific factor which appears during the end of intrafollicular maturation.
使用同一精子样本对体外成熟卵母细胞和新鲜排卵的卵母细胞进行受精的比较研究，揭示了哺乳动物卵母细胞成熟的一个新方面。虽然80%的新鲜排卵卵母细胞能够受精，但体外成熟的卵子却无法受精。它们仅在注射人绒毛膜促性腺激素（HCG）4至6小时后才具备被精子穿透的能力。因此，这并非输卵管的影响，而是取决于卵泡内成熟末期出现的一种卵母细胞特异性因子。
