Meng Ke, Zhu Jia, Zhang Tianyao, Zhang Xianzhe, Zhang Yingying, Chen Xiangjie, Li Fan, Tong Yao, Zhang Senhao, Qiu Donghai, Yang Hongbo, Liu Shangbin, Yin Lan, Zhao Rui, Huang Libin, Li Tao, Gao Min, Pan Taisong, Yang Jian, Cheng Huanyu, Lin Yuan
School of Materials and Energy, University of Electronic Science and Technology of China, Chengdu, 610054, China.
School of Materials and Energy, University of Electronic Science and Technology of China, Chengdu, 610054, China; Yangtze Delta Region Institute (Quzhou), University of Electronics Science and Technology of China, Quzhou, 324000, China.
Biosens Bioelectron. 2025 Nov 1;287:117677. doi: 10.1016/j.bios.2025.117677. Epub 2025 Jun 7.
Non-invasive, real-time, and continuous monitoring of trace amounts of glucose in near-neutral biofluids is significant for the daily care and treatment of diabetic patients or people with suboptimal health status. Despite improved sensing performance with novel low-dimensional materials or porous structures in various enzymatic and non-enzymatic electrochemical glucose sensors, they still suffer from high cost, poor long-term stability, and performance fluctuations in varied temperature and pH. This work synergistically combines an Au-modified porous laser-induced graphene (LIG) gate electrode with an organic electrochemical transistor (OECT) to create a flexible non-enzymatic glucose sensor. The resulting OECT-based non-enzymatic glucose sensor exhibits significantly enhanced sensitivity in near-neutral biofluids, the limit of detection (LOD) (0.08 μM in pH = 7.4), excellent stability over time (degradation of ∼10 % in 180 days) and against temperature changes (30 °C-40 °C), self-pH calibration capabilities, and uncompromised sensing performance with shrinking sizes. The highly consistent laser patterning technique and in situ galvanic reduction process for electrode modifications not only provide a simple yet versatile approach to creating low-cost, compact sensing platforms for precise and real-time sweat glucose measurements but also support scalable production, allowing the correlation study of key biomarkers in sweat and blood.
对近中性生物流体中的痕量葡萄糖进行无创、实时和连续监测，对于糖尿病患者或健康状况欠佳者的日常护理和治疗具有重要意义。尽管各种酶促和非酶促电化学葡萄糖传感器采用新型低维材料或多孔结构后传感性能有所改善，但它们仍面临成本高、长期稳定性差以及在不同温度和pH值下性能波动等问题。这项工作将金修饰的多孔激光诱导石墨烯（LIG）栅电极与有机电化学晶体管（OECT）协同结合，以创建一种柔性非酶促葡萄糖传感器。由此产生的基于OECT的非酶促葡萄糖传感器在近中性生物流体中表现出显著增强的灵敏度、检测限（pH = 7.4时为0.08 μM）、随时间的出色稳定性（180天内降解约10%）以及对温度变化（30°C - 40°C）的稳定性、自pH校准能力，并且在尺寸缩小时传感性能不受影响。高度一致的激光图案化技术和用于电极修饰的原位电偶还原过程不仅提供了一种简单而通用的方法来创建低成本、紧凑的传感平台，用于精确和实时的汗液葡萄糖测量，还支持可扩展生产，从而实现汗液和血液中关键生物标志物的相关性研究。
