Le Bouffant L, Izard C, Daniel H, Henin J P, Martin J C, Payen P
C R Acad Hebd Seances Acad Sci D. 1977 Mar 14;284(11):983-6.
When animals are exposed to cigarette smoke, the concentration of carbon monoxide in blood is rapidly increased, so that intensive inhalation tests cannot be carried out. A simple apparatus is described to expose Rats alternatively to cigarette smoke and to oxygen in order to reduce the concentration of carbon monoxide in the blood. This method makes it possible to increase the daily administration of smoke considerably; nevertheless, under such conditions, lung tumors were not observed.
当动物暴露于香烟烟雾中时,血液中的一氧化碳浓度会迅速升高,因此无法进行强化吸入试验。本文描述了一种简单的装置,可使大鼠交替暴露于香烟烟雾和氧气中,以降低血液中的一氧化碳浓度。这种方法可以显著增加每日烟雾的摄入量;然而,在这种条件下,并未观察到肺部肿瘤。