Kiviluoto T, Schröder T, Karonen S L, Kuusi T, Lempinen M, Taskinen M R
Ann Clin Res. 1985;17(3):110-5.
Carbohydrate and lipid metabolism were studied in 10 patients who had undergone total pancreatectomy. The results were compared with Type I diabetic patients and normal subjects, all of whom were matched for age, sex and weight. At the same level of glycemic control, the daily need for insulin was significantly lower in the patients with pancreatogenic diabetes than in those with Type I diabetes. Concentrations of serum total VLDL and HDL triglyceride were higher in the pancreatectomized patients than in the diabetic or normal controls, whereas concentrations of serum total and LDL cholesterol were significantly lower. The composition of the VLDL, LDL and HDL particles was abnormal in the totally pancreatectomized patients as all three lipoprotein fractions were enriched in triglyceride. HDL2 cholesterol was similar in the totally pancreatectomized patients to that in the other two groups but HDL3 cholesterol was lower. Postheparin plasma lipoprotein lipase and hepatic lipase activities were normal. It is concluded that in totally pancreatectomized patients the changes in the lipoprotein profile on reflect more the action of various confounding factors, i.e. malabsorption, continuance of alcohol abuse and dietary changes than the impact of the diabetes itself.
对10例接受全胰切除术的患者进行了碳水化合物和脂质代谢研究。将结果与1型糖尿病患者和正常受试者进行比较，所有这些患者在年龄、性别和体重方面均匹配。在相同的血糖控制水平下，胰腺源性糖尿病患者的每日胰岛素需求量显著低于1型糖尿病患者。全胰切除患者的血清总极低密度脂蛋白（VLDL）和高密度脂蛋白（HDL）甘油三酯浓度高于糖尿病或正常对照组，而血清总胆固醇和低密度脂蛋白（LDL）胆固醇浓度显著降低。全胰切除患者的VLDL、LDL和HDL颗粒组成异常，因为所有三种脂蛋白组分的甘油三酯含量均增加。全胰切除患者的HDL2胆固醇与其他两组相似，但HDL3胆固醇较低。肝素后血浆脂蛋白脂肪酶和肝脂肪酶活性正常。结论是，在全胰切除患者中，脂蛋白谱的变化更多地反映了各种混杂因素的作用，即吸收不良、持续酗酒和饮食变化，而不是糖尿病本身的影响。
