Navashin P S, Blatun L A
Antibiot Med Biotekhnol. 1985 Jul;30(7):516-20.
Antimicrobial activity of sisomicin against causative agents of wound infections was studied. It was shown that by its antimicrobial activity and the rate of bactericidal effect attainment sisomicin is superior to other aminoglycosides, such as gentamicin and tobramycin. Individual variability of the pharmacokinetics of sisomicin on its intravenous and intramuscular injection to patients with wound infections was observed. For prediction of the treatment efficacy it is suggested that the drug be used under the control of its blood levels in comparison to the MTC for the isolated causative agent.
研究了西索米星对伤口感染病原菌的抗菌活性。结果表明，就抗菌活性和达到杀菌效果的速率而言，西索米星优于其他氨基糖苷类药物，如庆大霉素和妥布霉素。观察到伤口感染患者静脉注射和肌肉注射西索米星后其药代动力学的个体差异。为预测治疗效果，建议在与分离出的病原菌的最低杀菌浓度相比较的血药浓度控制下使用该药物。
