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Klotho mitigates intervertebral disc degeneration by regulating autophagy and energy metabolism.

作者信息

Bahar Md Entaz, Lai Trang Huyen, Hwang Jin Seok, Ngo Quang Nhat, Maulidi Rizi Firman, Yang Jinsung, Kim Wanil, Yun Seung Pil, Lee Dong-Kun, Byun June-Ho, Kim Deok Ryong

机构信息

Department of Biochemistry and Convergence Medical Sciences and Institute of Medical Science, Gyeongsang National University College of Medicine, Jinju-si, Republic of Korea.

Department of Pharmacology and Convergence Medical Sciences and Institute of Medical Science, Gyeongsang National University College of Medicine, Jinju-si, Republic of Korea.

出版信息

Clin Transl Med. 2025 Jun;15(6):e70371. doi: 10.1002/ctm2.70371.

DOI:10.1002/ctm2.70371
PMID:40515445
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12166123/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a139/12166123/235a1d7b677d/CTM2-15-e70371-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a139/12166123/6234831801ab/CTM2-15-e70371-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a139/12166123/678bfebdf880/CTM2-15-e70371-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a139/12166123/b44ddfcc0425/CTM2-15-e70371-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a139/12166123/235a1d7b677d/CTM2-15-e70371-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a139/12166123/6234831801ab/CTM2-15-e70371-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a139/12166123/678bfebdf880/CTM2-15-e70371-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a139/12166123/b44ddfcc0425/CTM2-15-e70371-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a139/12166123/235a1d7b677d/CTM2-15-e70371-g002.jpg

相似文献

1
Klotho mitigates intervertebral disc degeneration by regulating autophagy and energy metabolism.α-klotho通过调节自噬和能量代谢减轻椎间盘退变。
Clin Transl Med. 2025 Jun;15(6):e70371. doi: 10.1002/ctm2.70371.
2
Autophagy as a potential therapeutic target in intervertebral disc degeneration.自噬作为椎间盘退变潜在的治疗靶点。
Life Sci. 2021 May 15;273:119266. doi: 10.1016/j.lfs.2021.119266. Epub 2021 Feb 22.
3
Antiaging Factor Klotho Retards the Progress of Intervertebral Disc Degeneration through the Toll-Like Receptor 4-NF-B Pathway.抗衰老因子α-klotho通过Toll样受体4-NF-κB通路延缓椎间盘退变进程。
Int J Cell Biol. 2020 Mar 19;2020:8319516. doi: 10.1155/2020/8319516. eCollection 2020.
4
M6A methylation-regulated autophagy may be a new therapeutic target for intervertebral disc degeneration.m6A甲基化调控的自噬可能是椎间盘退变的一个新的治疗靶点。
Cell Biol Int. 2024 Apr;48(4):389-403. doi: 10.1002/cbin.12135. Epub 2024 Feb 5.
5
Estradiol Alleviates Intervertebral Disc Degeneration through Modulating the Antioxidant Enzymes and Inhibiting Autophagy in the Model of Menopause Rats.雌二醇通过调节抗氧化酶和抑制绝经后大鼠模型中的自噬来缓解椎间盘退变。
Oxid Med Cell Longev. 2018 Dec 23;2018:7890291. doi: 10.1155/2018/7890291. eCollection 2018.
6
Role of autophagy in intervertebral disc degeneration.自噬在椎间盘退变中的作用。
J Cell Physiol. 2022 Feb;237(2):1266-1284. doi: 10.1002/jcp.30631. Epub 2021 Nov 17.
7
Role of Autophagy and Pyroptosis in Intervertebral Disc Degeneration.自噬和细胞焦亡在椎间盘退变中的作用
J Inflamm Res. 2024 Jan 6;17:91-100. doi: 10.2147/JIR.S434896. eCollection 2024.
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Exogenous Klotho ameliorates extracellular matrix degradation and angiogenesis in intervertebral disc degeneration via inhibition of the Rac1/PAK1/MMP-2 signaling axis.外源性 Klotho 通过抑制 Rac1/PAK1/MMP-2 信号轴改善椎间盘退变中外细胞外基质降解和血管生成。
Mech Ageing Dev. 2022 Oct;207:111715. doi: 10.1016/j.mad.2022.111715. Epub 2022 Aug 8.
9
Tension induces intervertebral disc degeneration via endoplasmic reticulum stress-mediated autophagy.张力通过内质网应激介导的自噬诱导椎间盘退变。
Biosci Rep. 2019 Aug 7;39(8). doi: 10.1042/BSR20190578. Print 2019 Aug 30.
10
Therapeutic effect of co-culture of rat bone marrow mesenchymal stem cells and degenerated nucleus pulposus cells on intervertebral disc degeneration.大鼠骨髓间充质干细胞与退变髓核细胞共培养对椎间盘退变的治疗作用。
Spine J. 2021 Sep;21(9):1567-1579. doi: 10.1016/j.spinee.2021.05.007. Epub 2021 May 14.

本文引用的文献

1
Reprogramming to restore youthful epigenetics of senescent nucleus pulposus cells for mitigating intervertebral disc degeneration and alleviating low back pain.重编程以恢复衰老髓核细胞的年轻表观遗传学，用于减轻椎间盘退变和缓解腰痛。
Bone Res. 2025 Mar 12;13(1):35. doi: 10.1038/s41413-025-00416-1.
2
Nucleus pulposus related lncRNA and mRNA expression profiles in intervertebral disc degeneration.椎间盘退变中与髓核相关的 lncRNA 和 mRNA 表达谱。
Genomics. 2023 Mar;115(2):110570. doi: 10.1016/j.ygeno.2023.110570. Epub 2023 Feb 4.
3
Exogenous Klotho ameliorates extracellular matrix degradation and angiogenesis in intervertebral disc degeneration via inhibition of the Rac1/PAK1/MMP-2 signaling axis.
外源性 Klotho 通过抑制 Rac1/PAK1/MMP-2 信号轴改善椎间盘退变中外细胞外基质降解和血管生成。
Mech Ageing Dev. 2022 Oct;207:111715. doi: 10.1016/j.mad.2022.111715. Epub 2022 Aug 8.
4
Klotho as Potential Autophagy Regulator and Therapeutic Target.作为潜在自噬调节因子和治疗靶点的klotho蛋白
Front Pharmacol. 2021 Oct 19;12:755366. doi: 10.3389/fphar.2021.755366. eCollection 2021.
5
Directed Differentiation of Notochord-like and Nucleus Pulposus-like Cells Using Human Pluripotent Stem Cells.人多能干细胞定向分化为脊索样细胞和髓核样细胞。
Cell Rep. 2020 Feb 25;30(8):2791-2806.e5. doi: 10.1016/j.celrep.2020.01.100.
6
Klotho: A Major Shareholder in Vascular Aging Enterprises.Klotho：血管老化企业的主要股东。
Int J Mol Sci. 2019 Sep 19;20(18):4637. doi: 10.3390/ijms20184637.
7
Lentivirus-mediated klotho up-regulation improves aging-related memory deficits and oxidative stress in senescence-accelerated mouse prone-8 mice.慢病毒介导的 klotho 上调改善了快速老化模型小鼠 8 （SAMP8）与衰老相关的记忆缺陷和氧化应激。
Life Sci. 2018 May 1;200:56-62. doi: 10.1016/j.lfs.2018.03.027. Epub 2018 Mar 13.
8
Disc cell senescence in intervertebral disc degeneration: Causes and molecular pathways.椎间盘退变中的椎间盘细胞衰老：原因及分子途径
Cell Cycle. 2016 Jul 2;15(13):1674-84. doi: 10.1080/15384101.2016.1152433. Epub 2016 May 18.
9
Aging and age related stresses: a senescence mechanism of intervertebral disc degeneration.衰老与年龄相关应激：椎间盘退变的一种衰老机制
Osteoarthritis Cartilage. 2016 Mar;24(3):398-408. doi: 10.1016/j.joca.2015.09.019. Epub 2015 Oct 9.