40岁以下患者的结直肠癌
Colorectal carcinoma in patients under age 40.
作者信息
Behbehani A, Sakwa M, Ehrlichman R, Maguire P, Friedman S, Steele G D, Wilson R E
出版信息
Ann Surg. 1985 Nov;202(5):610-4. doi: 10.1097/00000658-198511000-00013.
Patients under the age of 40 with colorectal cancer (29 females, 18 males) were compared with similar patients in our general hospital population and analyzed for patterns of presentation, stage at diagnosis, degree of tumor differentiation, and survival. There was a higher incidence of poorly differentiated tumors in the young patients (21% vs. 8% in the general population). Colon cancer in young adults was in a more advanced stage at presentation. The survival rate for young patients was 23% vs. 61% for the general population (p = 0.02). Stage C patients treated for cure had a survival rate of 56% in the general population compared with 34% in young adults (p = 0.05). The degree of tumor differentiation did not affect survival in those young patients undergoing curative resections (41% for well-differentiated and 30% for poorly differentiated cancers, p = 0.09). The median survival time by stage was: Stage A and B (N = 3) 36 months, Stage C (N = 26) 32 months, and Stage D (N = 18) 15.8 months. The need for early recognition of colorectal cancer in young adults is emphasized by the greater incidence of advanced disease and the high failure rate.
对40岁以下的结直肠癌患者（29名女性，18名男性）与我院普通住院患者中的类似患者进行了比较，并分析了其临床表现模式、诊断时的分期、肿瘤分化程度和生存率。年轻患者中低分化肿瘤的发生率较高（21%，而普通人群为8%）。年轻成年人的结肠癌在就诊时处于更晚期。年轻患者的生存率为23%，而普通人群为61%（p = 0.02）。接受根治性治疗的C期患者，普通人群的生存率为56%，而年轻成年人中为34%（p = 0.05）。肿瘤分化程度对接受根治性切除的年轻患者的生存率没有影响（高分化癌为41%，低分化癌为30%，p = 0.09）。按分期的中位生存时间为：A期和B期（N = 3）36个月，C期（N = 26）32个月，D期（N = 18）15.8个月。晚期疾病的较高发病率和高失败率强调了早期识别年轻成年人结直肠癌的必要性。
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