Ye Zheng, Dong Hui, Sui Fuyong
Department of Oral and Maxillofacial Surgery, the Second Hospital of Dalian Medical University, Dalian, Liaoning Province, China.
Department of Oral and Maxillofacial Surgery, the Second Hospital of Dalian Medical University, Dalian, Liaoning Province, China.
Int Dent J. 2025 Jun 13;75(4):100854. doi: 10.1016/j.identj.2025.100854.
To assess the value of preoperative peripheral blood inflammatory and nutritional parameters in distinguishing between benign and malignant parotid gland tumors.
A retrospective analysis was conducted on 79 patients with malignant parotid gland tumors and 79 patients with benign parotid gland tumors who were treated at the Second Hospital of Dalian Medical University from January 2015 to December 2024. Preoperative levels of total protein (TP), prealbumin (PA), albumin (Alb), albumin-to-globulin ratio (AGR), apolipoprotein A1-to-apolipoprotein B ratio (ApoA1/ApoB), and platelet-to-lymphocyte ratio (PLR) were compared between the malignant and benign tumor groups. The diagnostic value of these parameters in differentiating between benign and malignant parotid tumors was evaluated.
The ApoA1/ApoB ratio and PLR were significantly higher in the malignant tumor group compared to the benign tumor group (P < .05). Conversely, TP, Alb, PA, and AGR were significantly lower in the malignant tumor group than in the benign tumor group (P < .05). Binary logistic regression analysis identified TP, PA, AGR, and ApoA1/ApoB as independent risk factors for parotid malignancy (P < .05). The optimal cut-off values for diagnosing parotid malignancy were 65.75 for TP, 248.46 for PA, 1.55 for AGR, and 1.45 for ApoA1/ApoB.
Preoperative peripheral blood inflammatory and nutritional markers may serve as valuable indicators for differentiating between benign and malignant parotid gland tumors, providing a potential adjunctive diagnostic tool. However, further large-scale studies are required to validate these findings.
评估术前外周血炎症和营养参数在鉴别腮腺良恶性肿瘤中的价值。
对2015年1月至2024年12月在大连医科大学附属第二医院接受治疗的79例腮腺恶性肿瘤患者和79例腮腺良性肿瘤患者进行回顾性分析。比较恶性肿瘤组和良性肿瘤组术前总蛋白（TP）、前白蛋白（PA）、白蛋白（Alb）、白蛋白与球蛋白比值（AGR）、载脂蛋白A1与载脂蛋白B比值（ApoA1/ApoB）以及血小板与淋巴细胞比值（PLR）水平。评估这些参数在鉴别腮腺良恶性肿瘤中的诊断价值。
与良性肿瘤组相比，恶性肿瘤组的ApoA1/ApoB比值和PLR显著更高（P < 0.05）。相反，恶性肿瘤组的TP、Alb、PA和AGR显著低于良性肿瘤组（P < 0.05）。二元逻辑回归分析确定TP、PA、AGR和ApoA1/ApoB为腮腺恶性肿瘤的独立危险因素（P < 0.05）。诊断腮腺恶性肿瘤的最佳截断值分别为TP 65.75、PA 248.46、AGR 1.55和ApoA1/ApoB 1.45。
术前外周血炎症和营养标志物可能是鉴别腮腺良恶性肿瘤的有价值指标，提供了一种潜在的辅助诊断工具。然而，需要进一步的大规模研究来验证这些发现。
