Li Zhang-Juan, Hu Ming, Yuan Rong-Qing, Jia Ling, Ma Ya-Xuan, Liu Zhou, Shen Meng-Xia, Zhu Gui-Fa, Li Gan-Peng, Wu Xing-De
School of Ethnic Medicine and Key Laboratory of Ethnic Medicine Resource Chemistry, Ministry of Education, Yunnan Minzu University, Kunming 650504, China.
School of Ethnic Medicine and Key Laboratory of Ethnic Medicine Resource Chemistry, Ministry of Education, Yunnan Minzu University, Kunming 650504, China.
Fitoterapia. 2025 Sep;185:106680. doi: 10.1016/j.fitote.2025.106680. Epub 2025 Jun 12.
Four previously undescribed clerodane-type furanoditerpenoids, tinosagins A-D (1-4), were isolated from the tuberous roots of Tinospora sagittata (Oliv.) Gagnep., together with 11 known compounds (5-15). Their structures were determined by extensive spectroscopic analyses, electronic circular dichroism calculation, and single-crystal X-ray diffraction. Compound 1 was an unusual clerodane diterpenoid with 7,8-epoxy unit. All isolated compounds were evaluated for their inhibitory activity against α-glucosidase. The results indicated that 1 and 2 exhibited notable α-glucosidase inhibitory activity, with the IC values of 31.83 ± 0.83 and 47.35 ± 0.96 μM, respectively.
从中华青牛胆（Tinospora sagittata (Oliv.) Gagnep.）的块根中分离出4个新的克罗烷型呋喃二萜类化合物，锡生藤苷A-D（1-4），以及11个已知化合物（5-15）。通过广泛的光谱分析、电子圆二色性计算和单晶X射线衍射确定了它们的结构。化合物1是一种具有7,8-环氧单元的不寻常克罗烷二萜。对所有分离得到的化合物进行了α-葡萄糖苷酶抑制活性评价。结果表明，化合物1和2表现出显著的α-葡萄糖苷酶抑制活性，IC值分别为31.83±0.83和47.35±0.96μM。
