热带脾肿大综合征患者血清中的低分子量（7S）IgM和游离轻链。
Low molecular weight (7S) IgM and free light chains in the sera of patients with the tropical splenomegaly syndrome.
作者信息
Fakunle Y M, Greenwood B M
出版信息
Clin Exp Immunol. 1977 Apr;28(1):153-6.
The presence of naturally occurring LMW (7S) IgM was suspected on Sephadex G-200 filtration of a serum pool from patients with tropical splenomegaly syndrome (TSS). It was found in nineteen out of thirty-one sera from these patients using a polyacrylamide/agarose gel-diffusion method, and in fifteen of the sera after precipitation of the 19S IgM with 10% polyethylene glycol (PEG). Free K-light chains was detected in twenty-five out of thirty-one sera from patients with the TSS while free lambda-light chains was detected in four. The presence of 7S IgM and free light chains in sera of these patients is in keeping with our hypothesis that there is a disorder of control of immunoglobulin production in the tropical splenomegaly syndrome.
在对热带脾肿大综合征（TSS）患者血清池进行葡聚糖G - 200过滤时，怀疑存在天然存在的低分子量（7S）IgM。使用聚丙烯酰胺/琼脂糖凝胶扩散法，在这些患者的31份血清中有19份检测到了它，在用10%聚乙二醇（PEG）沉淀19S IgM后，在15份血清中检测到了它。在TSS患者的31份血清中有25份检测到了游离κ轻链，而在4份血清中检测到了游离λ轻链。这些患者血清中7S IgM和游离轻链的存在与我们的假设一致，即热带脾肿大综合征存在免疫球蛋白产生控制紊乱。
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