Alix D, Berthou F, Riche C, Gouedard H
Arch Fr Pediatr. 1985 Jun-Jul;42(6):465-9.
Theophylline has been administered to 76 premature infants with apnea in two therapeutic indications: curative and preventive treatment. Plasmatic theophylline and caffeine concentrations have been performed by gas chromatography for ten days for the determination of the therapeutic range. The maximum effective concentration has been defined from the data observed in 33 subjects presenting with symptoms considered as signs of toxicity. The minimum effective concentration has been determined from the data observed during the failure of treatment (n = 4) and at the reappearance of apnea at the end of treatment (n = 10). The therapeutic concentrations of theophylline has be found on average to be 3 to 8 mg/l and for the theophylline and caffeine together from 5 to 10 mg/l. The sum theophylline and caffeine data is better for therapeutic monitoring than the determination of theophylline alone.
已将氨茶碱用于76名患有呼吸暂停的早产儿，有两种治疗指征：治疗性和预防性治疗。采用气相色谱法测定了血浆中氨茶碱和咖啡因的浓度，持续十天以确定治疗范围。根据在33名出现被视为毒性体征症状的受试者中观察到的数据确定了最大有效浓度。根据治疗失败时（n = 4）和治疗结束时呼吸暂停再次出现时（n = 10）观察到的数据确定了最小有效浓度。已发现氨茶碱的治疗浓度平均为3至8毫克/升，氨茶碱和咖啡因的总浓度为5至10毫克/升。氨茶碱和咖啡因的数据总和用于治疗监测比单独测定氨茶碱更好。
