Brouard C, Moriette G, Murat I, Flouvat B, Pajot N, Walti H, de Gamarra E, Relier J P
Am J Dis Child. 1985 Jul;139(7):698-700. doi: 10.1001/archpedi.1985.02140090060028.
The purpose of our prospective randomized study was to compare the efficacy of theophylline ethylenediamine and caffeine sodium citrate in the treatment of idiopathic apnea in premature infants. Sixteen infants with three or more severe apneic attacks were studied. Twenty-four-hour cardiorespiratory recordings immediately before and after randomization and four days later showed similar significant decreases of the apnea frequency in both theophylline- (group 1, n = 8) and caffeine-treated infants (group 2, n = 8). No undesirable side effects were observed, except for tachycardia in one infant in group 1. We suggest reasons for preferring caffeine to theophylline in the control of idiopathic apnea in premature infants: caffeine is as efficient and easier to administer.
我们这项前瞻性随机研究的目的是比较氨茶碱和枸橼酸钠咖啡因治疗早产儿特发性呼吸暂停的疗效。研究了16例有三次或更多次严重呼吸暂停发作的婴儿。随机分组前、后及四天后的24小时心肺记录显示，氨茶碱治疗组（第1组，n = 8）和咖啡因治疗组（第2组，n = 8）的呼吸暂停频率均有显著下降。除第1组有1例婴儿出现心动过速外，未观察到不良副作用。我们提出在控制早产儿特发性呼吸暂停方面更倾向于使用咖啡因而非氨茶碱的理由：咖啡因同样有效且更易于给药。
