Soto Alvarez J, Sacristán del Castillo J A
Servicio de Farmacología Clínica, Hospital Marqués de Valdecilla, Santander.
An Esp Pediatr. 1991 Apr;34(4):310-2.
The simultaneous determination of caffeine and theophylline plasmatic levels has been proposed when the later is used in the treatment of the newborn's apnea. The caffeine plasmatic levels have been measured in five premature newborns treated with theophylline and the percentage of caffeine respect of theophylline, appraising its possible clinic repercusion. All the patients obtained theophylline levels into the therapeutic range proposed and a good efficacy was obtained without toxicity data, but there were a great interindividual variation in the amount of caffeine derived from theophylline (range from 12 to 50%). This result suggests the convenience of monitoring both drugs, especially when toxicity appear with theophylline levels into the therapeutic range.
当使用氨茶碱治疗新生儿呼吸暂停时，有人提议同时测定血浆中咖啡因和氨茶碱的水平。对5名接受氨茶碱治疗的早产新生儿测定了血浆咖啡因水平，并评估了咖啡因相对于氨茶碱的百分比，以评估其可能的临床影响。所有患者的氨茶碱水平均在建议的治疗范围内，且疗效良好，无毒性数据，但氨茶碱衍生的咖啡因量存在很大的个体差异（范围为12%至50%）。这一结果表明监测这两种药物是很有必要的，尤其是当氨茶碱水平处于治疗范围内出现毒性时。
