Liang Xiaolin, Zhang Xinyu, Liu Siyuan, Jin Ling, Young Charlotte Aimee, Ma Yiyuan, Zhou Ming, Zheng Danying, Jin Guangming
State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou, China.
Jiangmen Central Hospital, Jiangmen, Guangdong, China.
Eye (Lond). 2025 Jun 14. doi: 10.1038/s41433-025-03877-0.
To evaluate mental health among children with congenital ectopia lentis (CEL) and to develop an effective nomogram for predicting risk of mental health symptoms in CEL.
In total, 48 children with CEL and 50 control subjects aged 7-18 years old were enrolled in this study. Participants were required to complete the Children's Depression Inventory (CDI) and the Screen for Child Anxiety Related Emotional Disorders (SCARED) questionnaire to screen depressive and anxiety symptoms. Three potential predictors were tested and chosen to build a prediction model using logistic regression.
Compared with normal controls, CDI and SCARED scores were higher among children with CEL (P < 0.05). 35.4% of CEL children had varying degrees of depressive or anxiety symptoms. Child's age (odds ratio [OR] = 1.815, 95% confidence interval [CI], 1.084-3.039), duration of disease (OR = 1.557, 95% CI, 1.009-2.403), and systemic abnormalities (OR = 19.894, 95% CI, 1.660-238.463) were identified as predictors of anxiety symptoms. The combination of the above predictors shows good predictive ability, as indicated by area under the curve of 0.924 (95% CI, 0.845-1.000). The calibration curves showed good agreement between the prediction of the nomogram and the actual observations. Additionally, decision curve analysis showed that the nomogram was clinically useful and had better discriminatory power in identifying patients with significant anxiety symptoms.
Children with CEL experience higher level of depressive and anxiety symptoms. Child's age, duration of disease and systemic abnormalities are associated factors and can serve as useful indexes in predicting mental illness among CEL children.
评估先天性晶状体异位（CEL）患儿的心理健康状况，并开发一种有效的列线图以预测CEL患儿心理健康症状的风险。
本研究共纳入48例7至18岁的CEL患儿和50名对照受试者。参与者需完成儿童抑郁量表（CDI）和儿童焦虑相关情绪障碍筛查问卷（SCARED），以筛查抑郁和焦虑症状。测试并选择三个潜在预测因素，使用逻辑回归建立预测模型。
与正常对照组相比，CEL患儿的CDI和SCARED评分更高（P < 0.05）。35.4%的CEL患儿有不同程度的抑郁或焦虑症状。患儿年龄（比值比[OR]=1.815，95%置信区间[CI]，1.084 - 3.039）、病程（OR = 1.557，95% CI，1.009 - 2.403）和全身异常（OR = 19.894，95% CI，1.660 - 238.463）被确定为焦虑症状的预测因素。上述预测因素的组合显示出良好的预测能力，曲线下面积为0.924（95% CI，0.845 - 1.000）。校准曲线显示列线图预测与实际观察结果之间具有良好的一致性。此外，决策曲线分析表明列线图在临床上有用，并且在识别有明显焦虑症状的患者方面具有更好的鉴别力。
CEL患儿经历更高水平的抑郁和焦虑症状。患儿年龄、病程和全身异常是相关因素，可作为预测CEL患儿精神疾病的有用指标。
