Imai Y
Artif Organs. 1985 Aug;9(3):255-8. doi: 10.1111/j.1525-1594.1985.tb04388.x.
The effect of age on the calcification of biomaterials was studied by the subcutaneous implantation of poly(hydroxyethyl methacrylate) hydrogel in rats. The hydrogel sheets were implanted in rats 6, 12, 24, and 52 weeks (1 year) of age. The retrieved implants were compared and the percentage weight increase by mineralization was determined quantitatively. Significant differences in the rate and amount of calcification were observed between the growing (6 weeks old) and the adult (greater than or equal to 12 weeks of age) rats. The onset of calcification in the adult rats was significantly delayed. The immature rats had deposits three to four times as heavy as the mature rats.
通过在大鼠皮下植入聚甲基丙烯酸羟乙酯水凝胶，研究了年龄对生物材料钙化的影响。将水凝胶片植入6周、12周、24周和52周（1年）龄的大鼠体内。对取出的植入物进行比较，并定量测定矿化导致的重量增加百分比。在生长中的（6周龄）大鼠和成年（大于或等于12周龄）大鼠之间，观察到钙化速率和钙化量存在显著差异。成年大鼠的钙化开始明显延迟。未成熟大鼠的沉积物重量是成熟大鼠的三到四倍。
