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探索子宫内黏膜免疫的发育与功能。

Exploring mucosal immune development and function in utero.

作者信息

Strine Madison S, Vahkal Brett, St Denis Kerri, Konnikova Liza

机构信息

Department of Immunobiology, Yale School of Medicine, New Haven, CT, 06520, USA.

Department of Pediatrics, Yale School of Medicine, New Haven, CT, 06520, USA.

出版信息

Trends Immunol. 2025 Jul;46(7):502-504. doi: 10.1016/j.it.2025.05.004. Epub 2025 Jun 14.

DOI:10.1016/j.it.2025.05.004
PMID:40518358
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12255524/
Abstract

Multiomics advances have led to breakthroughs in understanding human early life immunity. Adaptive memory immune cells have been detected in fetal tissue extremely early in gestation, where they may respond to maternal exposures. These promising findings lay the groundwork for future research on the lifelong impact of early immune development.

摘要

多组学进展在理解人类早期生命免疫方面取得了突破。在妊娠极早期的胎儿组织中就检测到了适应性记忆免疫细胞，它们可能对母体暴露做出反应。这些有前景的发现为未来研究早期免疫发育的终身影响奠定了基础。

相似文献

1
Exploring mucosal immune development and function in utero.探索子宫内黏膜免疫的发育与功能。
Trends Immunol. 2025 Jul;46(7):502-504. doi: 10.1016/j.it.2025.05.004. Epub 2025 Jun 14.
2
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本文引用的文献

1
Spatial single-cell analysis identifies placental villi structuraland immune remodeling across gestation.空间单细胞分析揭示了整个孕期胎盘绒毛的结构和免疫重塑。
Mucosal Immunol. 2025 Aug;18(4):848-860. doi: 10.1016/j.mucimm.2025.04.005. Epub 2025 Apr 25.
2
Single-cell atlas of the small intestine throughout the human lifespan demonstrates unique features of fetal immune cells.人类生命全程小肠单细胞图谱显示胎儿免疫细胞的独特特征。
Mucosal Immunol. 2024 Aug;17(4):599-617. doi: 10.1016/j.mucimm.2024.03.011. Epub 2024 Mar 28.
3
Questioning the fetal microbiome illustrates pitfalls of low-biomass microbial studies.质疑胎儿微生物组说明了低生物量微生物研究的陷阱。
Nature. 2023 Jan;613(7945):639-649. doi: 10.1038/s41586-022-05546-8. Epub 2023 Jan 25.
4
Early microbial exposure shapes adult immunity by altering CD8+ T cell development.早期微生物暴露通过改变 CD8+T 细胞发育来塑造成人免疫。
Proc Natl Acad Sci U S A. 2022 Dec 6;119(49):e2212548119. doi: 10.1073/pnas.2212548119. Epub 2022 Nov 28.
5
Establishment of tissue-resident immune populations in the fetus.胎儿组织驻留免疫群体的建立。
Semin Immunopathol. 2022 Nov;44(6):747-766. doi: 10.1007/s00281-022-00931-x. Epub 2022 May 4.
6
Immune landscape of human placental villi using single-cell analysis.利用单细胞分析技术研究人类胎盘绒毛的免疫全景。
Development. 2022 Apr 15;149(8). doi: 10.1242/dev.200013. Epub 2022 Feb 17.
7
Prenatal maternal infection promotes tissue-specific immunity and inflammation in offspring.产前母体感染可促进子代组织特异性免疫和炎症反应。
Science. 2021 Aug 27;373(6558). doi: 10.1126/science.abf3002.
8
In utero human intestine harbors unique metabolome, including bacterial metabolites.子宫内的人类肠道拥有独特的代谢组，包括细菌代谢产物。
JCI Insight. 2020 Nov 5;5(21):138751. doi: 10.1172/jci.insight.138751.
9
Immune Cells in the Placental Villi Contribute to Intra-amniotic Inflammation.胎盘绒毛中的免疫细胞导致羊膜腔内炎症。
Front Immunol. 2020 May 22;11:866. doi: 10.3389/fimmu.2020.00866. eCollection 2020.
10
Maturation of the Human Intestinal Immune System Occurs Early in Fetal Development.人类肠道免疫系统的成熟发生在胎儿发育的早期。
Dev Cell. 2019 Nov 4;51(3):357-373.e5. doi: 10.1016/j.devcel.2019.09.008. Epub 2019 Oct 10.