探索子宫内黏膜免疫的发育与功能。
Exploring mucosal immune development and function in utero.
作者信息
Strine Madison S, Vahkal Brett, St Denis Kerri, Konnikova Liza
机构信息
Department of Immunobiology, Yale School of Medicine, New Haven, CT, 06520, USA.
Department of Pediatrics, Yale School of Medicine, New Haven, CT, 06520, USA.
出版信息
Trends Immunol. 2025 Jul;46(7):502-504. doi: 10.1016/j.it.2025.05.004. Epub 2025 Jun 14.
Abstract
Multiomics advances have led to breakthroughs in understanding human early life immunity. Adaptive memory immune cells have been detected in fetal tissue extremely early in gestation, where they may respond to maternal exposures. These promising findings lay the groundwork for future research on the lifelong impact of early immune development.
摘要
多组学进展在理解人类早期生命免疫方面取得了突破。在妊娠极早期的胎儿组织中就检测到了适应性记忆免疫细胞，它们可能对母体暴露做出反应。这些有前景的发现为未来研究早期免疫发育的终身影响奠定了基础。
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本文引用的文献
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Immune Cells in the Placental Villi Contribute to Intra-amniotic Inflammation.胎盘绒毛中的免疫细胞导致羊膜腔内炎症。
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